ArticlePsychopharmacology2014
The effect of chronic amphetamine treatment on cocaine-induced facilitation of intracranial self-stimulation in rats.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- The Effects of the Inhalant Toluene on Cognitive Function and Behavioral Flexibility: A Review of Recent Findings.Addiction neuroscience · 2023Article
- Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats.International journal of molecular sciences · 2021Article
- Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.Psychopharmacology · 2021Article
- Temporal parameters of enhanced opioid reward after initial opioid exposure in rats.Psychopharmacology · 2021Article
- A Strategy to Prioritize Emerging Drugs of Abuse for Analysis: Abuse Liability Testing Using Intracranial Self-Stimulation (ICSS) in Rats and Validation with α-Pyrrolidinohexanophenone (α-PHP).Emerging trends in drugs, addictions, and health · 2021Article
- Interactions between pain states and opioid reward assessed with intracranial self-stimulation in rats.Neuropharmacology · 2019Review
- Central leptin signaling transmits positive valence.Brain research · 2019Article
- Role of agonist efficacy in exposure-induced enhancement of mu opioid reward in rats.Neuropharmacology · 2019Article
- Cannabinoid CBBritish journal of pharmacology · 2019Article
- Effects of repeated treatment with methcathinone, mephedrone, and fenfluramine on intracranial self-stimulation in rats.Psychopharmacology · 2019Article
- Determinants of opioid abuse potential: Insights using intracranial self-stimulation.Peptides · 2019Review
- Interactions between Cocaine and the Putative Allosteric Dopamine Transporter Ligand SRI-31142.The Journal of pharmacology and experimental therapeutics · 2018Article
- Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Naltrexone maintenance fails to alter amphetamine effects on intracranial self-stimulation in rats.Experimental and clinical psychopharmacology · 2018Article
- Medications for substance use disorders (SUD): emerging approaches.Expert opinion on emerging drugs · 2017Review
- Opposing effects of dopamine D1- and D2-like agonists on intracranial self-stimulation in male rats.Experimental and clinical psychopharmacology · 2016Article
- Agonist Medications for the Treatment of Cocaine Use Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Effects of caffeine and its metabolite paraxanthine on intracranial self-stimulation in male rats.Experimental and clinical psychopharmacology · 2015Article
- A generalized matching law analysis of cocaine vs. food choice in rhesus monkeys: effects of candidate 'agonist-based' medications on sensitivity to reinforcement.Drug and alcohol dependence · 2015Article
- Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) in rats.European journal of pharmacology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleChronic amphetamine treatment reduces cocaine self-administration in pre-clinical and clinical settings, and amphetamine has been proposed as a candidate medication for treatment of cocaine abuse.
objectiveThe objective of the present study was to investigate whether chronic amphetamine treatment can decrease abuse-related cocaine effects in an assay of intracranial self-stimulation (ICSS).
methodsThirteen adult male Sprague-Dawley rats were equipped with intracranial electrodes targeting the medial forebrain bundle and trained to lever press for pulses of brain stimulation in a "frequency-rate" ICSS procedure. Cocaine (10 mg/kg) was administered before (day 0), during (days 7 and 14), and after (posttreatment days 1 and 3) 2 weeks of continuous treatment with either amphetamine (0.32 mg/kg/h, n = 7) or saline (n = 6) via osmotic pump.
resultsPrior to treatment, cocaine facilitated ICSS in all rats. Saline treatment had no effect on baseline ICSS or cocaine-induced facilitation of ICSS at any time. Conversely, amphetamine produced a sustained though submaximal facilitation of baseline ICSS, and cocaine produced little additional facilitation of ICSS during amphetamine treatment. Termination of amphetamine treatment produced a depression of baseline ICSS and recovery of cocaine-induced facilitation of ICSS.
conclusionsThese data suggest that chronic amphetamine treatment blunts expression of abuse-related cocaine effects on ICSS in rats.
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Registered trials
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