ArticlePsychopharmacology2014
Viral over-expression of D1 dopamine receptors in the prefrontal cortex increase high-risk behaviors in adults: comparison with adolescents.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 64 citations in OpenAlex.
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- Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
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- Age Effects Aggressive Behavior: RNA-Seq Analysis in Cattle with Implications for Studying Neoteny Under Domestication.Behavior genetics · 2022Article
- Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats.Frontiers in behavioral neuroscience · 2022Article
- The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period.Frontiers in neural circuits · 2022Review
- Is Adolescence a Sensitive Period for the Development of Incentive-Reward Motivation?Current topics in behavioral neurosciences · 2022Review
- Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus.International journal of bipolar disorders · 2021Article
- Risky decision-making following prefrontal D1 receptor manipulation.Translational neuroscience · 2021Article
- Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation.Addiction biology · 2020Article
- Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model.Journal of neurodevelopmental disorders · 2020Article
- The use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats.Heliyon · 2019Article
- Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats.eLife · 2019Article
- Stress, sensitive periods, and substance abuse.Neurobiology of stress · 2019Review
- Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine DPharmacology, biochemistry, and behavior · 2019Article
- Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats.Scientific reports · 2018Article
- Cued Reinstatement of Cocaine but Not Sucrose Seeking Is Dependent on Dopamine Signaling in Prelimbic Cortex and Is Associated with Recruitment of Prelimbic Neurons That Project to Contralateral Nucleus Accumbens Core.The international journal of neuropsychopharmacology · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAdolescents are often described as "lacking brakes" resulting in an increase in several behaviors associated with risk for addiction. Prefrontal cortex dopamine and cortico-limbic interaction play an important role in addiction, and we have previously shown that the dopamine D1 receptor is elevated on prelimbic prefrontal output neurons in adolescent rats. We hypothesized that a constellation of risk-related behaviors is mediated by prefrontal output neuron expression of D1.
objectivesWe aimed to determine the role of the dopamine D1 receptor in behavioral and neural correlates of risk for addiction that are often observed in adolescents. Therefore, high-risk behaviors as well as subcortical D2 receptor expression were investigated in adult animals with experimentally elevated D1 on prefrontal glutamatergic neurons.
methodsA lentiviral vector that selectively expressed the D1 receptor within glutamate neurons was injected in the prelimbic prefrontal cortex of adult male rats. Place conditioning to cocaine, alcohol, and nicotine, as well as delay discounting, novelty preferences, anxiety, cocaine self-administration, and sucrose preferences were assessed.
resultsVirally mediated D1 over-expression in adults leads to stronger drug-cue associations and greater consumption of sweet solutions, elevates bias towards immediate satisfaction rather than delaying gratification, decreases anxiety, and causes rats to work harder for and take more cocaine. Furthermore, elevated cortical D1 reduces D2 receptors in the accumbens (a putative risk marker).
conclusionsTogether, these data suggest a common mechanism for increased motivational drive to seek and consume substances with hedonic value, consistent with adolescent addictive processes.
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