ArticleBlood2014
EPCR: holy grail of malaria cytoadhesion?
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach.The American journal of tropical medicine and hygiene · 2015Review
- Review
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this issue of Blood, Aird et al review recent findings that suggest the endothelial protein C receptor (EPCR), known for its pivotal role in mediating cytoprotection against coagulopathy, proinflammatory cytokines, and vascular permeability, may serve as a receptor for Plasmodium falciparum-infected red blood cells (IRBCs) in the brain. In the process, coagulation is allowed to proceed unchecked and contributes to the pathogenesis of cerebral malaria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.