ArticleFunctional & integrative genomics2014
Quantitative resistance in potato leaves to late blight associated with induced hydroxycinnamic acid amides.
Article in Functional & integrative genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- Chemotaxis to plant defense compounds in phytopathogens.PLoS pathogens · 2026Article
- Engineered Production of Hydroxycinnamoyl Tyramine Conjugates Limits the Growth of the Pathogen Pseudomonas syringae in Arabidopsis.Plant, cell & environment · 2026Article
- When Metabolomics Meets Quantitative Genetics: An Integrative Strategy to Elucidate Plant Resistance Mechanisms.Plant, cell & environment · 2026Review
- Physiological, Chemical and Metabolite Profiling ofPlants (Basel, Switzerland) · 2025Article
- Characterization and Potential Role of Fatty Acid-Solamine Conjugates in Plant Defense against Herbivores and Pathogens in Wild Potato Species.Journal of agricultural and food chemistry · 2025Article
- Transcriptome Dynamics Underlying PlanticineInternational journal of molecular sciences · 2023Article
- Metabolic pathway genes for editing to enhance multiple disease resistance in plants.Journal of plant research · 2022Article
- Suberin Biosynthesis, Assembly, and Regulation.Plants (Basel, Switzerland) · 2022Review
- Both Constitutive and Infection-Responsive Secondary Metabolites Linked to Resistance againstMicroorganisms · 2022Article
- Bioinspired Rhamnolipid Protects Wheat AgainstFrontiers in plant science · 2022Article
- Comparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato andFrontiers in microbiology · 2022Article
- The Omics Hunt for Novel Molecular Markers of Resistance toPlants (Basel, Switzerland) · 2021Article
- Metabolic profiling for dissection of late leaf spot disease resistance mechanism in groundnut.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- The caffeoyl-CoA O-methyltransferase gene SNP replacement in Russet Burbank potato variety enhances late blight resistance through cell wall reinforcement.Plant cell reports · 2021Article
- Metabolomic Fingerprinting of Potato Cultivars Differing in Susceptibility to Spongospora subterranea f. sp. subterranea Root Infection.International journal of molecular sciences · 2020Article
- Adaptive defence-related changes in the metabolome of Sorghum bicolor cells in response to lipopolysaccharides of the pathogen Burkholderia andropogonis.Scientific reports · 2020Article
- A fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition.Nature communications · 2020Article
- Rice phenolamindes reduce the survival of female adults of the white-backed planthopper Sogatella furcifera.Scientific reports · 2020Article
- Article
- Insights on the Structural and Metabolic Resistance of Potato (Frontiers in plant science · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late blight is a serious economic threat to potato crop, sometimes leading to complete crop loss. The resistance in potato to late blight can be qualitative or quantitative in nature. Qualitative resistance is not durable. Though quantitative resistance is durable, the breeding is challenging due to polygenic inheritance. Several quantitative trait loci (QTLs) have been identified, but the mechanisms of resistance are largely unknown. A nontargeted metabolomics approach was used to identify resistance-related (RR) metabolites in a resistant genotype (F06025), as compared to a susceptible (Shepody) genotype, mock- or pathogen-inoculated. The RR metabolites, which had high fold change in abundance, mainly belonged to phenylpropanoid, flavonoid, fatty acid, and alkaloid chemical groups. The most important phenylpropanoids identified were hydroxycinnamic acid amides, the polyaromatic domain of suberin that is known to be associated with cell wall reinforcement. These metabolites were mapped on to the potato metabolic pathways, and the candidate enzymes and their coding genes were identified. A quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay revealed a higher upregulation of 4-coumarate: CoA ligase (4-CL), tyrosine decarboxylase (TyDC), and tyramine hydroxycinnamoyl transferase (THT) in the pathogen-inoculated resistant genotype than in susceptible. These genes were sequenced in both resistant and susceptible genotypes, and nonsynonymous single-nucleotide polymorphisms (nsSNPs) were found. The application of these genes in potato resistance improvement, following validation, is discussed.
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