SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Interleukin-6 -634C/G polymorphism is associated with lung cancer risk: a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Analysis of the correlation between combined multiple cytokine detection and colorectal cancer.Scientific reports · 2026Article
- New Insights on Old Biomarkers Involved in Tumor Microenvironment Changes and Their Diagnostic Relevance in Non-Small Cell Lung Carcinoma.Biomolecules · 2021Article
- Association of Variants in IL6-Related Genes with Lung Cancer Risk in Moroccan Population.Lung · 2019Article
- Immune-related gene polymorphisms in pulmonary diseases.Toxicology · 2017Review
- Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer.World journal of gastroenterology · 2017Article
- Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have examined the associations of polymorphisms in interleukin-6 (IL6) with lung cancer (LC) risk. However, the results were conflicting. Thus, a meta-analysis was conducted to determine the relationship between IL6 polymorphisms and LC risk. Databases including PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure (CNKI) were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Thirteen studies were included in this meta-analysis. Overall, a significant association between IL6 -634C/G polymorphism and LC susceptibility was observed for GG + CG vs. CC (OR = 1.33, 95% CI 1.20-1.47, P < 0.00001). This polymorphism was also significantly associated with LC risk in Asians (OR = 1.33, 95% CI 1.20-1.47, P < 0.00001), female patients (OR = 1.30, 95% CI 1.11-1.52, P = 0.0009), male patients (OR = 1.25, 95% CI 1.03-1.52, P = 0.02), non-small cell lung cancer patients (OR = 1.21, 95% CI 1.03-1.41, P = 0.02), small cell lung cancer patients (OR = 1.91, 95% CI 1.23-2.97, P = 0.004), smokers (OR = 1.42, 95% CI 1.21-1.65, P < 0.0001), and non-smokers (OR = 1.32, 95% CI 1.13-1.53, P = 0.0003), respectively. No significant result was found for IL6 -174C/G polymorphism. This meta-analysis suggested that IL6 -634C/G polymorphism was a risk factor for LC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.