ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Gastrokine-2 is downregulated in gastric cancer and its restoration suppresses gastric tumorigenesis and cancer metastasis.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Significance ofInternational journal of medical sciences · 2024Article
- Low-level gastrokine 2 promoted progress of NSCLC and as a potential biomarker.Journal of clinical laboratory analysis · 2022Article
- NK6 Homeobox 2 Regulated Gastrokin-2 Suppresses Gastric Cancer Cell Proliferation and Invasion via Akt Signaling Pathway.Cell biochemistry and biophysics · 2021Article
- Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential.Frontiers in oncology · 2021Article
- Gastrokine 2 Regulates the Antitumor Effect of JAK2/STAT3 Pathway in Gastric Cancer.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Coordinate expression loss ofAmerican journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Prognostic Value of Gastrokine-2 (GKN2) and Its Correlation with Tumor-Infiltrating Immune Cells in Lung Cancer and Gastric Cancers.Journal of inflammation research · 2020Article
- The role and diagnostic potential of gastrokine 1 in gastric cancer.Cancer management and research · 2019Review
- Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer.Gastroenterology and hepatology from bed to bench · 2018Article
- Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017Article
- GKN2 increases apoptosis, reduces the proliferation and invasion ability of gastric cancer cells through down-regulating the JAK/STAT signaling pathway.American journal of translational research · 2017Article
- Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3β signaling in gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression.The Journal of clinical investigation · 2016Article
- Potential role of aquaporin 3 in gastric intestinal metaplasia.Oncotarget · 2015Article
- Trophoblast expression dynamics of the tumor suppressor gene gastrokine 2.Histochemistry and cell biology · 2015Article
- Introducing biomarker panel in esophageal, gastric, and colon cancers; a proteomic approach.Gastroenterology and hepatology from bed to bench · 2015Review
- Characterization of differentially expressed genes involved in pathways associated with gastric cancer.PloS one · 2015Article
- The role of gastrokine 1 in gastric cancer.Journal of gastric cancer · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrokine-2 (GKN2) is a secretory protein that is decreased or absent in gastric cancer tissues. In addition, it is reported that trefoil factor 1 (TFF1) and TFF2 can both bind GKN2. In this study, we investigated the expression and biological functions of GKN2 and its interaction with TFF2 in gastric cancer. We found that GKN2 expression was significantly downregulated or absent in gastric cancer cell lines, gastric intestinal metaplasia, and tumor tissues. Overexpression of GKN2 suppressed the proliferation, migration, and invasion of gastric cancer cells and arrested the cell cycle at the G1-S transition phase. Furthermore, GKN2 efficiently attenuated tumor growth in SGC-7901 nude mice xenograft models. Overexpression of GKN2 also reduced the expression levels of cylinD1, cyclinE1, and matrix metalloproteinase 9 (MMP9), which were correlated with proliferation and metastasis of cancer cells. In co-transfected cells, TFF2 and GKN2 did not bind to each other. Overexpression of both GKN2 and TFF2 showed the same inhibitory effect as overexpression of GKN2 alone. Taken together, these findings suggested that GKN2 could inhibit the proliferation, migration, and invasion of gastric cancer cells and might represent a novel therapeutic target for gastric cancer. TFF2 may not interact or cooperate with GKN2, either structurally or functionally.
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Registered trials
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