Evidence map›Paper›PMID 24407989›Full record

Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2014

Diagnostic performance and limitations of magnifying narrow-band imaging in screening endoscopy of early gastric cancer: a prospective multicenter feasibility study.

Kenshi Yao, Hisashi Doyama, Takuji Gotoda, Hideki Ishikawa, Takashi Nagahama, Chizu Yokoi, Ichiro Oda, Hirohisa Machida, Kunihisa Uchita, Masahiko Tabuchi

Registry-linked trialAbstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02385578 (An Educational Intervention, the First Step of the Train the Trainer), which is not on this map. Cited by 87 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02385578 naunknown statusnot on this mapstarted 2015, after this paper: background citation

An Educational Intervention, the First Step of the Train the Trainer (TTT) Plan, to Improve the Young Endoscopist's Ability to Find the Early Gastric Cancer:Prospective Study With Historical Control

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2015 to 2016Enrolled16,000ConditionsEarly Gastric CancerArmsan educational intervention
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Comparison of the diagnostic efficacy of white light endoscopy and magnifying endoscopy with narrow band imaging for early gastric cancer: a meta-analysis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016
    Pooled it
  4. Pooled it
  5. [The value of narrow-band imaging with magnifying endoscopy in diagnosis of early gastric cancer: a meta-analysis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2015
    Pooled it
  6. Trial
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  9. Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017
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  12. Upper Gastrointestinal Endoscopy in Elderly Patients: An Individualized Decision-Making Approach for Screening and Surveillance.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Review
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  14. Article
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  18. Endoscopic Diagnosis of Remnant Gastric Cancer After Gastrectomy.The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Review
  19. Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kenshi YaoDepartment of Endoscopy, Central Research Institute for Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka University, 1-1-1 Zokumyoin, Chikushino, Fukuoka, 818-8502, Japan, yao@fukuoka-u.ac.jp.
Hisashi Doyama
Takuji Gotoda
Hideki Ishikawa
Takashi Nagahama
Chizu Yokoi
Ichiro Oda
Hirohisa Machida
Kunihisa Uchita
Masahiko Tabuchi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurative treatment of patients with gastric cancer requires reliable detection of early gastric cancer. Magnifying endoscopy with narrow-band imaging (M-NBI) is useful for the accurate preoperative diagnosis of early gastric cancer. However, the role of M-NBI in screening endoscopy has not been established. The aims of this study were to determine the feasibility and limitations of M-NBI in screening endoscopy.

methodsWe conducted a multicenter prospective uncontrolled trial of patients undergoing routine screening endoscopy patients. We determined the diagnostic accuracy, sensitivity and specificity of M-NBI according to the degree of certainty and need for biopsy, as assessed using the VS (vessel plus surface) classification system. We analyzed the endoscopic and histopathological characteristics of both false negative and false positive high confidence M-NBI diagnoses. We then developed a provisional diagnostic strategy based on the diagnostic performance and limitations identified in this study.

resultsA total of 1097 patients were enrolled in the study. We analyzed 371 detected lesions (20 cancers and 351 non-cancers). The accuracy, sensitivity and specificity of high confidence M-NBI diagnoses were 98.1, 85.7 and 99.4 %, respectively. The false negative case was a pale mucosal lesion with tissue diagnosis of signet-ring cell carcinoma. Exclusion of pale mucosal lesions increased the accuracy, sensitivity and specificity of high confidence M-NBI diagnoses to 99.4, 100 and 99.4 %, respectively. We therefore propose a practical strategy targeting non-pale mucosal lesions.

conclusionsWith a refined strategy considering its limitations, M-NBI can act as an "optical biopsy" in screening endoscopies.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Signet Ring CellFalse Negative ReactionsFeasibility StudiesFemaleGastroscopyHumansMaleMiddle AgedProspective StudiesSensitivity and SpecificityStomach Neoplasms

Identifiers

PMID24407989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.