ArticleClinical rheumatology2015
Pain threshold and intensity in rheumatic patients: correlations with the Hamilton Depression Rating scale.
Article in Clinical rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Pulsed electromagnetic fields in knee osteoarthritis: a double blind, placebo-controlled, randomized clinical trial.Rheumatology (Oxford, England) · 2016Trial
- Article
- Towards an individualised approach to pain management in inflammatory arthritis.Therapeutic advances in musculoskeletal disease · 2026Review
- Central Sensitization and Nociplastic Pain: Shared Mechanisms in Fibromyalgia, Osteoarthritis, and Inflammatory Arthritis.Journal of pain research · 2026Review
- Reduced trapezius pressure pain threshold in fibromyalgia and opioid use.The journal of pain · 2025Article
- Reference Values of Joint-Specific Pressure Pain Thresholds in Healthy Male Individuals: A Retrospective Study.European journal of pain (London, England) · 2025Article
- Factors Associated with Depression, Anxiety, and Sleep Disturbance Among Patients with Moderate-to-Severe Chronic Pain: A Multicenter Cross-Sectional Study.Journal of pain research · 2025Article
- Effect of Exercise Interventions for Rheumatoid Arthritis: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.Journal of pain research · 2025Review
- An interdisciplinary perspective on peripheral drivers of pain in rheumatoid arthritis.Nature reviews. Rheumatology · 2024Review
- Minocycline Abrogates Individual Differences in Nerve Injury-Evoked Affective Disturbances in Male Rats and Prevents Associated Supraspinal Neuroinflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Pressure Pain Thresholds and Central Sensitization in Relation to Psychosocial Predictors of Chronicity in Low Back Pain.Diagnostics (Basel, Switzerland) · 2023Article
- Biological sex influences psychological aspects of the biopsychosocial model related to chronic pain intensity and interference among South Korean patients with chronic secondary musculoskeletal pain in rheumatic diseases.Frontiers in psychology · 2023Article
- The Impact and Correlation of Anxiety and Depression on Pressure Pain Threshold of Acupoints in Patients with Chronic Pelvic Inflammatory Disease.Pain research & management · 2023Article
- Pain sensitivity in young adults with juvenile idiopathic arthritis: a quantitative sensory testing study.Arthritis research & therapy · 2020Article
- Patient-Centered Care in Psoriatic Arthritis-A Perspective on Inflammation, Disease Activity, and Psychosocial Factors.Journal of clinical medicine · 2020Review
- Association of neuropathic-like pain characteristics with clinical and radiographic features in patients with ankylosing spondylitis.Clinical rheumatology · 2018Article
- Widespread pain in axial spondyloarthritis: clinical importance and gender differences.Arthritis research & therapy · 2018Article
- Pain threshold and temporomandibular function in systemic sclerosis: comparison with psoriatic arthritis.Clinical rheumatology · 2018Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals suffering from chronic pain are frequently affected by depression, which in turn increases the risk of developing chronic pain over time. This study aims to investigate the relationship between depression and pain intensity and threshold in a group of rheumatic patients compared to healthy subjects. One hundred twenty-four individuals of whom 50 were affected by rheumatoid arthritis (RA), 23 by psoriatic arthritis (PsA), 23 by ankylosing spondylitis (AS), and 28 age-matched controls without chronic pain underwent quantitative sensory testing to assess pressure pain threshold with pressure algometry. Pain intensity was evaluated through the visual analogue scale (VAS) and depression through the Hamilton Depression Rating scale (HAMD). A significant inverse correlation between HAMD values and pressure pain thresholds was found in the entire group of patients (p < 0.0001), in controls (p = 0.02), and also in RA (p = 0.002), PsA (p < 0.0002), and AS (p = 0.02) patients when analyzed separately, while no significant correlation was found between HAMD and VAS values or pressure pain thresholds and VAS. We found lower pain thresholds in RA and PsA patients while no difference has been evidenced in AS patients compared to healthy controls. HAMD scores were also significantly higher in rheumatic patients than in controls. The use of pressure algometry in the evaluation of chronic pain in patients affected by rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis that display comorbid depression could represent an additional and integrative method to improve pain/depression overlap management or research.
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