ArticleJournal of biomedical materials research. Part B, Applied biomaterials2014
Chitosan-cellulose composite for wound dressing material. Part 2. Antimicrobial activity, blood absorption ability, and biocompatibility.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 109 citations in OpenAlex.
- State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding.International wound journal · 2024Review
- Multifunctional Sodium Hyaluronate/Chitosan Foam Used as an Absorbable Hemostatic Material.Bioengineering (Basel, Switzerland) · 2023Article
- Sustainable Approach of Functional Biomaterials-Tissue Engineering for Skin Burn Treatment: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Fungal Carboxymethyl Chitosan-Impregnated Bacterial Cellulose Hydrogel as Wound-Dressing Agent.Gels (Basel, Switzerland) · 2023Article
- Inorganic-based biomaterials for rapid hemostasis and wound healing.Chemical science · 2022Review
- Inactivation of SARS-CoV-2 by a chitosan/α-AgScientific reports · 2022Article
- Natural-Fiber-Reinforced Chitosan, Chitosan Blends and Their Nanocomposites for Various Advanced Applications.Polymers · 2022Review
- Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications.Marine drugs · 2020Review
- Fabrication of Cellulose Nanocrystal/Chitosan Hydrogel for Controlled Drug Release.Nanomaterials (Basel, Switzerland) · 2019Article
- SIKVAV-Modified Chitosan Hydrogel as a Skin Substitutes for Wound Closure in Mice.Molecules (Basel, Switzerland) · 2018Article
- Smart Wound Dressings for Diabetic Chronic Wounds.Bioengineering (Basel, Switzerland) · 2018Review
- Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery.International wound journal · 2018Review
- Peptide SIKVAV-modified chitosan hydrogels promote skin wound healing by accelerating angiogenesis and regulating cytokine secretion.American journal of translational research · 2018Article
- Chitin and chitosan: biopolymers for wound management.International wound journal · 2017Review
- Peptide-Modified Chitosan Hydrogels Accelerate Skin Wound Healing by Promoting Fibroblast Proliferation, Migration, and Secretion.Cell transplantation · 2017Article
- Peptide-modified chitosan hydrogels promote skin wound healing by enhancing wound angiogenesis and inhibiting inflammation.American journal of translational research · 2017Article
- Synthesis, structure and antimicrobial property of green composites from cellulose, wool, hair and chicken feather.Carbohydrate polymers · 2016Article
- Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing.Journal of biomedical materials research. Part A · 2016Article
- Cellulose, Chitosan and Keratin Composite Materials: Facile and Recyclable Synthesis, Conformation and Properties.ACS sustainable chemistry & engineering · 2016Article
- Challenges of Complex Open Abdominal Wound Management in Trauma: A Novel Use of Chitosan and Hyaluronic Acid as a 3-Dimensional Scaffold to Overcome Resilient Open Abdomen Infections.The journal of the American College of Clinical Wound Specialists · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chitosan (CS), a polysaccharide derived from chitin, the second most abundant polysaccharide, is widely used in the medical world because of its natural and nontoxic properties and its innate ability for antibacterial and hemostasis effects. In this study, the novel composites containing CS and cellulose (CEL) (i.e., [CEL + CS]), which we have previously synthesized using a green and totally recyclable method, were investigated for their antimicrobial activity, absorption of anticoagulated whole blood, anti-inflammatory activity through the reduction of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and the biocompatibility with human fibroblasts. The [CEL + CS] composites were found to inhibit the growth of both Gram positive and negative micro-organisms. For examples, the regenerated 100% lyophilized chitosan material was found to reduce growth of Escherichia coli (ATCC 8739 and vancomycin resistant Enterococcus faecalis (ATCC 51299) by 78, 36, and 64%, respectively. The composites are nontoxic to fibroblasts; that is, fibroblasts, which are critical to the formation of connective tissue matrix were found to grow and proliferate in the presence of the composites. They effectively absorb blood, and at the same rate and volume as commercially available wound dressings. The composites, in both air-dried and lyophilized forms, significantly inhibit the production of TNF-α and IL-6 by stimulated macrophages. These results clearly indicate that the biodegradable, biocompatible and nontoxic [CEL + CS] composites, particularly those dried by lyophilizing, can be effectively used as a material in wound dressings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.