ArticleEuropean archives of psychiatry and clinical neuroscience2014
High social support buffers the effects of 5-HTTLPR genotypes within social anxiety disorder.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Influence of the COVID-19 Pandemic on Social Anxiety: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Role of Family Decision-Making and Perceived Social Support in the Mental Health of Mothers of Infants in Rural Western China.Depression and anxiety · 2025Trial
- Effects of the CALM intervention on resilience in Chinese patients with early breast cancer: a randomized trial.Journal of cancer research and clinical oncology · 2023Trial
- Screening for social anxiety disorder in students of Jordan universities after COVID-19 pandemic: a cross-sectional survey study.BMJ open · 2025Article
- The association between family adaptability and adolescent depression: the chain mediating role of social support and self-efficacy.Frontiers in psychology · 2024Article
- Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults.Development and psychopathology · 2023Article
- Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety.Translational psychiatry · 2023Article
- Effect of social support on anxiety of medical staff one year after COVID-19 outbreak: a moderated mediating model.Scientific reports · 2022Article
- Mediating Effect of Emotional and Social Competences on Interrelations Between Gender, Age and the Broad Autism Phenotype.Journal of autism and developmental disorders · 2021Article
- Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications.Current psychiatry reports · 2019Review
- Parenting Interacts with Oxytocin Polymorphisms to Predict Adolescent Social Anxiety Symptom Development: A Novel Polygenic Approach.Journal of abnormal child psychology · 2019Article
- Influence of 5-HTT variation, childhood trauma and self-efficacy on anxiety traits: a gene-environment-coping interaction study.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Historical aspects of Mozart's mental health and diagnostic insights of ADHD and personality disorders.European archives of psychiatry and clinical neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An interaction between genetic aspects and environmental stressors has been suggested with regard to the etiology of social anxiety disorder (SAD). However, potential protective interplays which might decrease the risk of SAD have not been considered so far. Thus, we analyzed the interaction between 5-HTTLPR and differing levels of social support regarding SAD. The sample was based on participants of the Study of Health in Pomerania, Germany. We used the triallelic genotype of 5-HTTLPR and longitudinal data of social support. Final analyses were conducted in 79 individuals with SAD and 1,708 without. The diagnosis of SAD was derived from diagnostic interviews in accordance with DSM-IV. Considering the risk of SAD, a general protective effect of high social support was shown independent of variation in 5-HTTLPR genotype. In contrast, the risk of SAD was increased for both genotypes within those individuals with low social support. Additionally, the odds ratio for suffering from SAD was about two times higher for carriers of the l/l genotype compared to those with at least one short allele in those perceiving less-supportive social environments. The findings suggest that SAD is influenced by a protective and a contributing gene × environment interaction. High social support might act in a protective and low social support in an increasing manner on the risk of SAD especially within carriers of the l/l genotype. Therefore, effects of 5-HTTLPR might be buffered by high social support with respect to the risk of SAD.
Indexed as
Identifiers
24407753What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.