ReviewProgress in neurobiology2014
Non-pharmaceutical therapies for stroke: mechanisms and clinical implications.
Review in Progress in neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Resting-state functional abnormalities in ischemic stroke: a meta-analysis of fMRI studies.Brain imaging and behavior · 2024Pooled it
- Efficacy and safety of hyperbaric oxygen therapy in acute ischaemic stroke: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- Cellular and Molecular Targets for Non-Invasive, Non-Pharmacological Therapeutic/Rehabilitative Interventions in Acute Ischemic Stroke.International journal of molecular sciences · 2022Pooled it
- The effects of intravenous laser irradiation of blood with red and blue light on stroke risk biomarkers and neurological function: a double blind randomized controlled trial.Lasers in medical science · 2025Trial
- Acupuncture for acute moderate thalamic hemorrhage: randomized controlled trial study protocol.BMC complementary and alternative medicine · 2017Trial
- Delta-opioid receptor-mediated neural protection and regeneration.Neural regeneration research · 2026Article
- Applications of Carbonic Anhydrase Inhibitors in Arthritis, Neuropathic Pain, Acute Mountain Sickness, and Cerebral Ischemia.Sub-cellular biochemistry · 2026Review
- Mechanisms of electroacupuncture-induced neuroprotection in acute stroke rats: the role of astrocyte-mediated mitochondrial transfer.Cell communication and signaling : CCS · 2025Article
- Hypoxia in multiple sclerosis.Redox biology · 2025Review
- Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability.ACS medicinal chemistry letters · 2024Article
- Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations.Biomedicines · 2023Review
- Acupuncture for autophagy in animal models of middle cerebral artery occlusion: A systematic review and meta-analysis protocol.PloS one · 2023Article
- COVID-19 Vaccination Is Associated with a Better Outcome in Acute Ischemic Stroke Patients: A Retrospective Observational Study.Journal of clinical medicine · 2022Article
- Review
- Review on Laser Technology in Intravascular Imaging and Treatment.Aging and disease · 2022Review
- Peripheral Organ Injury After Stroke.Frontiers in immunology · 2022Review
- Protective effects of carbonic anhydrase inhibition in brain ischaemiaJournal of enzyme inhibition and medicinal chemistry · 2021Article
- Article
- Effect of Electroacupuncture on Neurological Deficit and Activity of Clock and Bmal1 in Cerebral Ischemic Rats.Current medical science · 2020Article
- Hyperbaric oxygen therapy in acute stroke: is it time for Justitia to open her eyes?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Stroke is deemed a worldwide leading cause of neurological disability and death, however, there is currently no promising pharmacotherapy for acute ischemic stroke aside from intravenous or intra-arterial thrombolysis. Yet because of the narrow therapeutic time window involved, thrombolytic application is very restricted in clinical settings. Accumulating data suggest that non-pharmaceutical therapies for stroke might provide new opportunities for stroke treatment. Here we review recent research progress in the mechanisms and clinical implications of non-pharmaceutical therapies, mainly including neuroprotective approaches such as hypothermia, ischemic/hypoxic conditioning, acupuncture, medical gases and transcranial laser therapy. In addition, we briefly summarize mechanical endovascular recanalization devices and recovery devices for the treatment of the chronic phase of stroke and discuss the relative merits of these devices.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.