ArticleNature communications2014
A fully genetically encoded protein architecture for optical control of peptide ligand concentration.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 citations in OpenAlex.
- Design of a light and CaProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Design of Ultrapotent Genetically Encoded Inhibitors of Kv4.2 for Gating Neural Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches.Journal of the American Chemical Society · 2023Article
- Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches.RSC chemical biology · 2022Review
- A guide to the optogenetic regulation of endogenous molecules.Nature methods · 2021Review
- Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors.Nature communications · 2021Article
- Tethered peptide neurotoxins display two blocking mechanisms in the KScience advances · 2020Article
- Pore-modulating toxins exploit inherent slow inactivation to block KProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Optical control of neuronal ion channels and receptors.Nature reviews. Neuroscience · 2019Review
- Optically inducible membrane recruitment and signaling systems.Current opinion in structural biology · 2019Review
- Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.Journal of the American Chemical Society · 2019Article
- Optogenetic control of integrin-matrix interaction.Communications biology · 2019Article
- Blue-Light Receptors for Optogenetics.Chemical reviews · 2018Review
- Potassium channel-based optogenetic silencing.Nature communications · 2018Article
- State-of-the-Art Techniques to Causally Link Neural Plasticity to Functional Recovery in Experimental Stroke Research.Neural plasticity · 2018Review
- Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition.Frontiers in neuroscience · 2018Article
- Following Optogenetic Dimerizers and Quantitative Prospects.Biophysical journal · 2016Review
- Optical Control of Peroxisomal Trafficking.ACS synthetic biology · 2016Article
- Optimizing optogenetic constructs for control over signaling and cell behaviours.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2015Review
- Location matters: somatic and dendritic SK channels answer to distinct calcium signals.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ion channels are among the most important proteins in biology, regulating the activity of excitable cells and changing in diseases. Ideally it would be possible to actuate endogenous ion channels, in a temporally precise and reversible manner, and without requiring chemical cofactors. Here we present a modular protein architecture for fully genetically encoded, light-modulated control of ligands that modulate ion channels of a targeted cell. Our reagent, which we call a lumitoxin, combines a photoswitch and an ion channel-blocking peptide toxin. Illumination causes the photoswitch to unfold, lowering the toxin's local concentration near the cell surface, and enabling the ion channel to function. We explore lumitoxin modularity by showing operation with peptide toxins that target different voltage-dependent K(+) channels. The lumitoxin architecture may represent a new kind of modular protein-engineering strategy for designing light-activated proteins, and thus may enable development of novel tools for modulating cellular physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.