ArticleScientific reports2014
Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
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- Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging.Aging cell · 2021Article
- Anti-inflammatory role of TPCA-1 encapsulated nanosomes in porcine chondrocytes against TNF-α stimulation.Inflammopharmacology · 2019Article
- Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.PLoS biology · 2018Article
- Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells.Scientific reports · 2018Article
- Bacterial secretion systems and regulation of inflammasome activation.Journal of leukocyte biology · 2017Review
- Targeting NF-κB in glioblastoma: A therapeutic approach.Science advances · 2016Article
- Ambiguine I Isonitrile fromInternational journal of cancer research · 2015Article
- MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis.British journal of pharmacology · 2015Article
- Ginsenoside Rg3 Inhibits Constitutive Activation of NF-κB Signaling in Human Breast Cancer (MDA-MB-231) Cells: ERK and Akt as Potential Upstream Targets.Journal of cancer prevention · 2014Article
- The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Monocyte-derived antigen presenting cells (APC) are central mediators of the innate and adaptive immune response in inflammatory diseases. As such, APC are appropriate targets for therapeutic intervention to ameliorate certain diseases. APC differentiation, activation and functions are regulated by the NF-κB family of transcription factors. Herein, we examined the effect of NF-κB inhibition, via suppression of the IκB Kinase (IKK) complex, on APC function. Murine bone marrow-derived macrophages and dendritic cells (DC), as well as macrophage and DC lines, underwent rapid programmed cell death (PCD) after treatment with several IKK/NF-κB inhibitors through a TNFα-dependent mechanism. PCD was induced proximally by reactive oxygen species (ROS) formation, which causes a loss of mitochondrial membrane potential and activation of a caspase signaling cascade. NF-κB-inhibition-induced PCD of APC may be a key mechanism through which therapeutic targeting of NF-κB reduces inflammatory pathologies.
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