ArticlePlant physiology2014
A novel rice cytochrome P450 gene, CYP72A31, confers tolerance to acetolactate synthase-inhibiting herbicides in rice and Arabidopsis.
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Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 134 citations in OpenAlex.
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- Molecular Mechanisms of Herbicide Resistance in Rapeseed: Current Status and Future Prospects for Resistant Germplasm Development.International journal of molecular sciences · 2025Review
- Function of cytochrome P450 CYP72A1182 in metabolic herbicide resistance evolution in Amaranthus palmeri populations.Journal of experimental botany · 2025Article
- The Genome of Lolium multiflorum Reveals the Genetic Architecture of Paraquat Resistance.Molecular ecology · 2025Article
- Transcriptomic analysis reveals cloquintocet-mexyl-inducible genes in hexaploid wheat (Triticum aestivum L.).PloS one · 2025Article
- Toxicological qualities and detoxification trends of fruit by-products for valorization: A review.Open life sciences · 2025Review
- A Computational Pipeline Observes the Flexibility and Dynamics of Plant Cytochrome P450 Binding Sites.International journal of molecular sciences · 2024Article
- Assessment of ACC and P450 Genes Expression in Wild Oat (Avena ludoviciana) in Different Tissues Under Herbicide Application.Biochemical genetics · 2023Article
- Genome-Wide Identification and Expression Profiling of Cytochrome P450 Monooxygenase Superfamily in Foxtail Millet.International journal of molecular sciences · 2023Article
- Molecular Characterization of Resistance to Nicosulfuron inInternational journal of molecular sciences · 2023Article
- Distinctive physiological and molecular responses of foxtail millet and maize to nicosulfuron.Frontiers in plant science · 2023Article
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- Multiple Resistance Mechanisms Involved in Glyphosate Resistance inPlants (Basel, Switzerland) · 2022Article
- Characterization of Cytochrome P450s with Key Roles in Determining Herbicide Selectivity in Maize.ACS omega · 2022Article
- Expression of a Cytochrome P450 Gene from Bermuda GrassPlants (Basel, Switzerland) · 2022Article
- Cytochrome P450 CYP709C56 metabolizing mesosulfuron-methyl confers herbicide resistance in Alopecurus aequalis.Cellular and molecular life sciences : CMLS · 2022Article
- Breeding rice for a changing climate by improving adaptations to water saving technologies.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
- Catalytic promiscuity of rice 2-oxoglutarate/Fe(II)-dependent dioxygenases supports xenobiotic metabolism.Plant physiology · 2021Article
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Authors and funding
14 authors at 5 institutions in 1 country.
Hiroaki SaikaAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Junko HoritaAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Fumio Taguchi-ShiobaraAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Satoko NonakaAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Ayako Nishizawa-YokoiAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Satoshi IwakamiAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Kiyosumi HoriAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Takashi MatsumotoAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Tsuyoshi TanakaAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Takeshi ItohAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Masahiro YanoAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Koichiro KakuAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Tsutomu ShimizuAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.).
Seiichi TokiAgrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan (H.S., F.T.-S., A.N.-Y., K.H., T.M., T.T., T.I., M.Y., S.T.);Life Science Research Institute, Kumiai Chemical Industry, Kakegawa, Shizuoka 439-0031, Japan (J.H., K.K., T.S.);Graduate School of Life and Environmental Sciences, Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan (S.N.);Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan (S.I.); andKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa 244-0813, Japan (S.T.) stoki@affrc.go.jp.
Institute of Agrobiological Sciences · JPKumiai Chemical Industry (Japan) · JPKyoto University · JPUniversity of Tsukuba · JPYokohama City University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Target-site and non-target-site herbicide tolerance are caused by the prevention of herbicide binding to the target enzyme and the reduction to a nonlethal dose of herbicide reaching the target enzyme, respectively. There is little information on the molecular mechanisms involved in non-target-site herbicide tolerance, although it poses the greater threat in the evolution of herbicide-resistant weeds and could potentially be useful for the production of herbicide-tolerant crops because it is often involved in tolerance to multiherbicides. Bispyribac sodium (BS) is an herbicide that inhibits the activity of acetolactate synthase. Rice (Oryza sativa) of the indica variety show BS tolerance, while japonica rice varieties are BS sensitive. Map-based cloning and complementation tests revealed that a novel cytochrome P450 monooxygenase, CYP72A31, is involved in BS tolerance. Interestingly, BS tolerance was correlated with CYP72A31 messenger RNA levels in transgenic plants of rice and Arabidopsis (Arabidopsis thaliana). Moreover, Arabidopsis overexpressing CYP72A31 showed tolerance to bensulfuron-methyl (BSM), which belongs to a different class of acetolactate synthase-inhibiting herbicides, suggesting that CYP72A31 can metabolize BS and BSM to a compound with reduced phytotoxicity. On the other hand, we showed that the cytochrome P450 monooxygenase CYP81A6, which has been reported to confer BSM tolerance, is barely involved, if at all, in BS tolerance, suggesting that the CYP72A31 enzyme has different herbicide specificities compared with CYP81A6. Thus, the CYP72A31 gene is a potentially useful genetic resource in the fields of weed control, herbicide development, and molecular breeding in a broad range of crop species.
Indexed as
Herbicide ResistanceAcetolactate SynthaseArabidopsisBase SequenceBenzoatesCrops, AgriculturalCytochrome P-450 Enzyme SystemHerbicidesMolecular Sequence DataOryzaPlant ProteinsPlant RootsPlants, Genetically ModifiedPlant ShootsPyrimidinesSequence Analysis, DNAAcetolactate SynthaseBenzoatesbispyribacCytochrome P-450 Enzyme SystemHerbicidesPlant ProteinsPyrimidines
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