ArticleInternational journal of molecular sciences2014
Dual drug release electrospun core-shell nanofibers with tunable dose in the second phase.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 75 citations in OpenAlex.
- Scientific Research Trend on Guided Tissue Regeneration: A Bibliometric Analysis.European journal of dentistry · 2025Article
- A Hybrid Electrospun-Extruded Polydioxanone Suture for Tendon Tissue Regeneration.Tissue engineering. Part A · 2024Article
- Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers' Architecture.Pharmaceutics · 2022Review
- Cellulose-Based Nanofibers Processing Techniques and Methods Based on Bottom-Up Approach-A Review.Polymers · 2022Review
- Investigation on the Mass Distribution and Chemical Compositions of Various Ionic Liquids-Extracted Coal Fragments and Their Effects on the Electrochemical Performance of Coal-Derived Carbon Nanofibers (CCNFs).Nanomaterials (Basel, Switzerland) · 2021Article
- Scale-up of Electrospinning: Market Overview of Products and Devices for Pharmaceutical and Biomedical Purposes.Pharmaceutics · 2021Review
- New Acaciin-Loaded Self-Assembled Nanofibers as MInternational journal of nanomedicine · 2021Article
- Functional Nanofibrous Biomaterials of Tailored Structures for Drug Delivery-A Critical Review.Pharmaceutics · 2020Review
- Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model.Frontiers in bioengineering and biotechnology · 2020Article
- Article
- Fabrication and Characterization of Core-Shell Electrospun Fibrous Mats Containing Medicinal Herbs for Wound Healing and Skin Tissue Engineering.Marine drugs · 2019Article
- Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering.Tissue engineering and regenerative medicine · 2017Review
- The Electrospun Ceramic Hollow Nanofibers.Nanomaterials (Basel, Switzerland) · 2017Review
- Physicochemical and biological characteristics of BMP-2/IGF-1-loaded three-dimensional coaxial electrospun fibrous membranes for bone defect repair.Journal of materials science. Materials in medicine · 2017Article
- Nanoparticles and nanofibers for topical drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2016Review
- Electrospun Fibers for Drug Delivery after Spinal Cord Injury and the Effects of Drug Incorporation on Fiber Properties.Cells, tissues, organs · 2016Article
- Application of Wnt Pathway Inhibitor Delivering Scaffold for Inhibiting Fibrosis in Urethra Strictures: In Vitro and in Vivo Study.International journal of molecular sciences · 2015Article
- Nanofibrous scaffolds in biomedical applications.Biomaterials research · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study reports a new type of drug-loaded core-shell nanofibers capable of providing dual controlled release with tunable dose in the second phase. The core-shell nanofibers were fabricated through a modified coaxial electrospinning using a Teflon-coated concentric spinneret. Poly(vinyl pyrrolidone) and ethyl cellulose were used as the shell and core polymer matrices respectively, and the content of active ingredient acetaminophen (APAP) in the core was programmed. The Teflon-coated concentric spinneret may facilitate the efficacious and stable preparation of core-shell nanofibers through the modified coaxial electrospinning, where the core fluids were electrospinnable and the shell fluid had no electrospinnability. The resultant nanofibers had linear morphologies and clear core-shell structures, as observed by the scanning and transmission electron microscopic images. APAP was amorphously distributed in the shell and core polymer matrices due to the favorite second-order interactions, as indicated by the X-ray diffraction and FTIR spectroscopic tests. The results from the in vitro dissolution tests demonstrated that the core-shell nanofibers were able to furnish the desired dual drug controlled-release profiles with a tunable drug release amount in the second phase. The modified coaxial electrospinning is a useful tool to generate nanostructures with a tailored components and compositions in their different parts, and thus to realize the desired functional performances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.