ReviewEye (London, England)2014
Molecular pathogenesis and management strategies of ectopia lentis.
Review in Eye (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Excessive Stretching Drives RPE Inflammation and ECM Remodeling in Ectopia Lentis Retinopathy.International journal of molecular sciences · 2026Article
- Clinical and Surgical Implications of Genotype-Phenotype Correlations in Congenital Ectopia Lentis: A Real-World Cohort Study.Investigative ophthalmology & visual science · 2026Article
- A de novo FBN1 variant likely causes congenital bilateral ectopia lentis in a crossbred horse.Scientific reports · 2025Article
- Complex Microphthalmia in Three Central Asian Shepherd Dogs.Veterinary medicine and science · 2025Article
- Refractive Alterations in Marfan Syndrome: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Case Report:Frontiers in genetics · 2025Article
- Review
- Longitudinal changes of refractive error in preschool children with congenital ectopia lentis.International ophthalmology · 2024Article
- Clinical and Genetic Landscape of Ectopia Lentis Based on a Cohort of Patients From 156 Families.Investigative ophthalmology & visual science · 2024Article
- Article
- Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanism of Disease: Recessive ADAMTSL4 Mutations and Craniosynostosis with Ectopia Lentis.Case reports in genetics · 2022Article
- Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients.Journal of ophthalmology · 2022Article
- Recurrent Intraocular Lens Dislocation in a Patient with Familial Ectopia Lentis.International journal of environmental research and public health · 2021Article
- Genotype variant screening and phenotypic analysis ofMolecular medicine reports · 2021Article
- Whole-exome sequencing identified a novel homozygous ASPH frameshift variant causing Traboulsi syndrome in a Chinese family.Molecular genetics & genomic medicine · 2021Article
- Are patients with ectopia lentis known to cardiology services?Eye (London, England) · 2019Article
- Article
- Non-cardiac manifestations of Marfan syndrome.Annals of cardiothoracic surgery · 2017Review
- How far is observation allowed in patients with ectopia lentis?SpringerPlus · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ectopia lentis (EL) is a condition that can either herald underlying systemic conditions, or be isolated. The recent expansion in the genetics of these conditions has furthered the understanding of the underlying molecular aetiology. It is becoming apparent that novel genes, and in particular the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, are important in ocular development. The common link in these genes seems to be EL. The clinical management of EL is challenging. In particular, the options for addressing surgically induced aphakia in the context of an ectopic capsule are varied. Little evidence exists to direct management of these issues. This review summarises the molecular pathogenesis of EL and conditions associated with it, using the genetic aetiology as a framework. Furthermore, it summarises some of the issues involved in its clinical management.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.