Evidence map›Paper›PMID 24406145›Full record

ReviewThe Lancet. Infectious diseases2014

Perinatally acquired HIV infection in adolescents from sub-Saharan Africa: a review of emerging challenges.

Elizabeth D Lowenthal, Sabrina Bakeera-Kitaka, Tafireyi Marukutira, Jennifer Chapman, Kathryn Goldrath, Rashida A Ferrand

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 284 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 10 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 10 syntheses or guidelines pooled it, 466 citations in OpenAlex.

  1. Evidence Gaps in Economic Evaluations of HIV Interventions Targeting Young People: A Systematic Review.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2024
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224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Elizabeth D LowenthalDepartments of Pediatrics and Epidemiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA; Department of Paediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Botswana-UPenn Partnership, Gaborone, Botswana.
Sabrina Bakeera-KitakaDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Tafireyi MarukutiraBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Jennifer ChapmanDepartment of Paediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kathryn GoldrathDepartments of Pediatrics and Epidemiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Rashida A FerrandFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK; Biomedical Research and Training Institute, Harare, Zimbabwe. Electronic address: rashida.ferrand@lshtm.ac.uk.
Biomedical Research and Training Institute · ZWBotswana-Baylor Children's Clinical Center of Excellence · BWBotswana Open University · BWChildren's Hospital of Philadelphia · USMakerere University · UGUniversity of Pennsylvania · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Targeted Monitoring and Determinants of Adherence in Adolescents with HIVK23MH095669 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI LOWENTHAL, ELIZABETH DAWN · 2012 to 2016
$874k
NIAID NIH HHS P30 AI045008NIMH NIH HHS K23 MH095669NIMH NIH HHS MH095669PEPFARWellcome Trust 095878/Z/11/ZWellcome Trust 100714
6 · The paper itself

Abstract

Worldwide, more than three million children are infected with HIV, 90% of whom live in sub-Saharan Africa. As the HIV epidemic matures and antiretroviral treatment is scaled up, children with HIV are reaching adolescence in large numbers. The growing population of adolescents with perinatally acquired HIV infection living within this region presents not only unprecedented challenges but also opportunities to learn about the pathogenesis of HIV infection. In this Review, we discuss the changing epidemiology of paediatric HIV and the particular features of HIV infection in adolescents in sub-Saharan Africa. Longstanding HIV infection acquired when the immune system is not developed results in distinctive chronic clinical complications that cause severe morbidity. As well as dealing with chronic illness, HIV-infected adolescents have to confront psychosocial issues, maintain adherence to drugs, and learn to negotiate sexual relationships, while undergoing rapid physical and psychological development. Context-specific strategies for early identification of HIV infection in children and prompt linkage to care need to be developed. Clinical HIV care should integrate age-appropriate sexual and reproductive health and psychological, educational, and social services. Health-care workers will need to be trained to recognise and manage the needs of these young people so that the increasing numbers of children surviving to adolescence can access quality care beyond specialist services at low-level health-care facilities.

Indexed as

AdolescentAfrica South of the SaharaDelivery of Health CareHIVHIV InfectionsHumansSexual Behavior

Identifiers

PMID24406145
PMCPMC4074242
OpenAlexW2163264029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.