SynthesisBMC musculoskeletal disorders2014
Are depression, anxiety and poor mental health risk factors for knee pain? A systematic review.
Synthesis in BMC musculoskeletal disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Psychological Interventions Added to Standard Care Improve Pain and Function Outcomes in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Musculoskeletal care · 2025Pooled it
- Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review.The Cochrane database of systematic reviews · 2018Pooled it
- Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.Nutrients · 2023Trial
- A comparison of psychological characteristics in people with knee osteoarthritis from Japan and Australia: A cross-sectional study.PloS one · 2022Trial
- Effect of a Positive Psychological Intervention on Pain and Functional Difficulty Among Adults With Osteoarthritis: A Randomized Clinical Trial.JAMA network open · 2018Trial
- Testing a Positive Psychological Intervention for Osteoarthritis.Pain medicine (Malden, Mass.) · 2017Trial
- Knee pain and related health in the community study (KPIC): a cohort study protocol.BMC musculoskeletal disorders · 2017Trial
- Article
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- Brain-bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Preoperative anxiety in patients undergoing minimally invasive thoracic surgery: A prospective study of predictors and Patient-Reported concerns.Scientific reports · 2025Article
- Longitudinal study of knee pain amongst workers in the Cultural and Psychosocial Influences on Disability (CUPID) study.BMC musculoskeletal disorders · 2025Article
- Genetic liability to meniscus degeneration and its comorbidity patterns: a phenome-wide association study in the UK Biobank.medRxiv : the preprint server for health sciences · 2025Article
- Relationship between adverse childhood experiences and musculoskeletal pain: the mediating effect of depressive symptoms.BMC psychology · 2025Article
- Prevalence of Knee Pain and Its Relation to Depression, Anxiety, and Health-Related Quality of Life Among Maintenance Hemodialysis Patients.Journal of clinical medicine · 2025Article
- Prevalence of mental health disorders in knee osteoarthritis patients: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Review
- Exploration beyond osteoarthritis: the association and mechanism of its related comorbidities.Frontiers in endocrinology · 2024Review
- Influence of Knee Osteoarthritis Severity, Knee Pain, and Depression on Physical Function: A Cross-Sectional Study.Clinical interventions in aging · 2024Article
- Genetic link between depression and musculoskeletal disorders: insights from Mendelian randomization analysis.Frontiers in medicine · 2024Article
- Depression and assets during the COVID-19 pandemic: A longitudinal study of mental health across income and savings groups.PloS one · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile it is recognized that psychosocial factors are important in the development and progression of musculoskeletal pain and disability, no systematic review has specifically focused on examining the relationship between psychosocial factors and knee pain. We aimed to systematically review the evidence to determine whether psychosocial factors, specifically depression, anxiety and poor mental health, are risk factors for knee pain.
methodsElectronic searches of MEDLINE, EMBASE and PsycINFO were performed to identify relevant studies published up to August 2012 using MESH terms and keywords. We included studies that met a set of predefined criteria and two independent reviewers assessed the methodological quality of the selected studies. Due to the heterogeneity of the studies, a best evidence synthesis was performed.
resultsSixteen studies were included in the review, of which 9 were considered high quality. The study populations were heterogeneous in terms of diagnosis of knee pain. We found a strong level of evidence for a relationship between depression and knee pain, limited evidence for no relationship between anxiety and knee pain, and minimal evidence for no relationship between poor mental health and knee pain.
conclusionsDespite the heterogeneity of the included studies, these data show that depression plays a significant role in knee pain, and that a biopsychosocial approach to the management of this condition is integral to optimising outcomes for knee pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.