ArticleClinical biomechanics (Bristol, Avon)2014
An animal model to evaluate skin-implant-bone integration and gait with a prosthesis directly attached to the residual limb.
Article in Clinical biomechanics (Bristol, Avon), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Biocompatibility Analysis of the Silver-Coated Microporous Titanium Implants Manufactured with 3D-Printing Technology.Nanomaterials (Basel, Switzerland) · 2024Article
- Comparison In Vitro Study on the Interface between Skin and Bone Cell Cultures and Microporous Titanium Samples Manufactured with 3D Printing Technology Versus Sintered Samples.Nanomaterials (Basel, Switzerland) · 2024Article
- Transforming the Anthropomorphic Passive Free-Flow Foot Prosthesis Into a Powered Foot Prosthesis With Intuitive Control and Sensation (Bionic FFF).Military medicine · 2024Article
- Electrical Stimulation of Distal Tibial Nerve During Stance Phase of Walking May Reverse Effects of Unilateral Paw Pad Anesthesia in the Cat.Motor control · 2023Article
- Biomechanical Tests on Long-Bone Elliptical Medullary-Canal Endoprostheses for Limb Salvage in Dogs.Animals : an open access journal from MDPI · 2022Article
- Biomechanical Test of a New Endoprosthesis for Cylindrical Medullary Canals in Dogs.Frontiers in veterinary science · 2022Article
- Protecting the skin-implant interface with transcutaneous silver-coated skin-and-bone-integrated pylon in pig and rabbit dorsum models.Journal of biomedical materials research. Part B, Applied biomaterials · 2021Article
- Recent Progress in Animal Studies of the Skin- and Bone-integrated Pylon With Deep Porosity for Bone-Anchored Limb Prosthetics With and Without Neural Interface.Military medicine · 2021Review
- Antibacterial Peptide HHC-36 Sustained-Release Coating Promotes Antibacterial Property of Percutaneous Implant.Frontiers in bioengineering and biotechnology · 2021Article
- Evaluation of the temporary effect of physical vapor deposition silver coating on resistance to infection in transdermal skin and bone integrated pylon with deep porosity.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Implantation of an Intraosseous Transcutaneous Amputation Prosthesis Restoring Ambulation After Amputation of the Distal Aspect of the Left Tibia in an Arabian Tahr (Frontiers in veterinary science · 2019Article
- Kinetics of individual limbs during level and slope walking with a unilateral transtibial bone-anchored prosthesis in the cat.Journal of biomechanics · 2018Article
- Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.EC orthopaedics · 2018Article
- Osseointegrated Transcutaneous Device for Amputees: A Pilot Large Animal Model.Advances in orthopedics · 2018Article
- A Prototype of a Neural, Powered, Transtibial Prosthesis for the Cat: Benchtop Characterization.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite the number of advantages of bone-anchored prostheses, their use in patients is limited due to the lack of complete skin-implant integration. The objective of the present study was to develop an animal model that would permit both detailed investigations of gait with a bone-anchored limb prosthesis and histological analysis of the skin-implant-bone interface after physiological loading of the implant during standing and walking.
methodsFull-body mechanics of walking in two cats were recorded and analyzed before and after implantation of a percutaneous porous titanium pylon into the right tibia and attachment of a prosthesis. The rehabilitation procedures included initial limb casting, progressively increasing loading on the implant, and standing and locomotor training. Detailed histological analysis of bone and skin ingrowth into implant was performed at the end of the study.
findingsThe two animals adopted the bone-anchored prosthesis for standing and locomotion, although loads on the prosthetic limb during walking decreased by 22% and 62%, respectively, 4months after implantation. The animals shifted body weight to the contralateral side and increased propulsion forces by the contralateral hindlimb. Histological analysis of the limb implants demonstrated bone and skin ingrowth.
interpretationThe developed animal model to study prosthetic gait and tissue integration with the implant demonstrated that porous titanium implants may permit bone and skin integration and prosthetic gait with a bone-anchored prosthesis. Future studies with this model will help optimize the implant and prosthesis properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.