ArticleJournal of psychiatric research2014
Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol.
Article in Journal of psychiatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 99 citations in OpenAlex.
- Do blood plasma levels of oxytocin moderate the effect of nasally administered oxytocin on social orienting in high-functioning male adults with autism spectrum disorder?Psychopharmacology · 2016Trial
- Potential preventive effects of forest bathing/Shinrin-yoku on depressive symptoms: a narrative review of mechanistic evidence.Environmental health and preventive medicine · 2026Review
- Towards Objective Major Depressive Disorder Detection: a Systematic Review and Meta-Analysis of Diagnostic Biomarkers.The Psychiatric quarterly · 2025Review
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Guilt and shame and its relation to oxytocin in patients with depression and alcohol addiction.BMC psychiatry · 2025Article
- Impacts of Forest Bathing (Shinrin-Yoku) in Female Participants with Depression/Depressive Tendencies.Diseases (Basel, Switzerland) · 2025Article
- Tales from the life and lab of a female social neuroscientist.Comprehensive psychoneuroendocrinology · 2023Review
- [Oxytocin and vasopressin: sexual differences and clinical implications].Revista medica del Instituto Mexicano del Seguro Social · 2023Review
- Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders.Comprehensive psychoneuroendocrinology · 2023Article
- Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits.Neuroscience and biobehavioral reviews · 2022Review
- Utility of Downstream Biomarkers to Assess and Optimize Intranasal Delivery of Oxytocin.Pharmaceutics · 2022Article
- OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study.Journal of molecular neuroscience : MN · 2022Article
- Immunological and other biological correlates of the impact of antenatal depression on the mother-infant relationship.Brain, behavior, & immunity - health · 2022Article
- Depressive symptomatology, temperament and oxytocin serum levels in a sample of healthy female university students.BMC psychology · 2022Article
- Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression.Journal of clinical medicine · 2021Article
- Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother-newborn dyads.Translational psychiatry · 2021Article
- LC-MS/MS measurement of endogenous oxytocin in the posterior pituitary and CSF of macaques: A pilot study.Peptides · 2021Article
- Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways.Scientific reports · 2021Article
- Neuroprotective Effect of Aurantio-Obtusin, a Putative Vasopressin VInternational journal of molecular sciences · 2021Article
- Oxytocin Signaling as a Target to Block Social Defeat-Induced Increases in Drug Abuse Reward.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The neuropeptide oxytocin (OT) promotes social behavior and attenuates stress responsivity in mammals. Recent clinical evidence suggests OT concentrations may be dysregulated in major depression. This study extends previous research by testing whether: 1) OT concentrations vary systematically in depressive disorders with and without hypercortisolemia, 2) gender differences in OT concentrations are observed in depressed vs. healthy control participants, and 3) OT concentrations are predictive of clinical phenotypes. Plasma OT concentrations of psychotic major depressive (PMD; n = 14: 10 female, 4 male), non-psychotic major depressive (NPMD; n = 17: 12 female, 5 male), and non-depressed, healthy control (n = 19: 11 female, 8 male) participants were assayed at 2000, 2400, 0400, and 0800 h. Plasma cortisol concentrations were quantified at 2300 h, and clinical phenotypes were determined. As expected, PMD participants, compared to NPMD and healthy control participants, showed higher plasma cortisol concentrations. Although both depressed groups showed similar OT concentrations, a significant interaction effect between group and gender was observed. Specifically, depressed females exhibited lower mean OT concentrations than depressed males. Further, depressed vs. healthy control female participants exhibited lower mean OT concentrations, whereas depressed vs. healthy control male participants showed a trend in the opposite direction. OT concentrations were also predictive of desirability, drug dependence, and compulsivity scores as measured by the Million Clinical Multiaxial Inventory-III. All findings were independent of cortisol. These data suggest that OT signaling may provide a mechanism by which to better understand female-biased risk to develop depressive disorders and that plasma OT concentrations may be a useful biomarker of certain clinical phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.