ArticleJournal of neurotrauma2014
Gait analysis at multiple speeds reveals differential functional and structural outcomes in response to graded spinal cord injury.
Article in Journal of neurotrauma, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Early high‑frequency spinal cord stimulation modulates the ROS/p38 MAPK/NF‑κB and CXCL10/CXCR3 pathways to alleviate neuropathic pain and promote spinal cord injury repair.International journal of molecular medicine · 2026Article
- Unbiased quantification of persistent postural and motor deficits following spinal cord injury in mice.PloS one · 2026Article
- Recovery in gait and posture: a network-based approach to the assessment of rehabilitation effectiveness after spinal cord injury.Frontiers in network physiology · 2026Article
- A longitudinal rat forelimb model for assessing in vivo neuromuscular function following extremity reperfusion injury.Lab animal · 2025Article
- Manual assessment of cylinder rearing behavior is more sensitive than automated gait evaluations in young, male mice post-stroke of the forepaw somatosensory cortex.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Article
- Daily electric field treatment improves functional outcomes after thoracic contusion spinal cord injury in rats.Nature communications · 2025Article
- Poly(glycerol succinate) hydrogel promotes spinal cord repair by regulating bio-energetic activity in severe injury.Materials today. Bio · 2025Article
- An observational study of lower limb muscle imbalance assessment and gait analysis of badminton players.Frontiers in bioengineering and biotechnology · 2024Article
- Spinal control of locomotion before and after spinal cord injury.Experimental neurology · 2023Article
- Spinal control of locomotion before and after spinal cord injury.bioRxiv : the preprint server for biology · 2023Article
- Comparison of Walking Quality Variables between End-Stage Osteonecrosis of Femoral Head Patients and Healthy Subjects by a Footscan Plantar Pressure System.Medicina (Kaunas, Lithuania) · 2022Article
- Activity dependent stimulation increases synaptic efficacy in spared pathways in an anesthetized rat model of spinal cord contusion injury.Restorative neurology and neuroscience · 2022Article
- Mechanobiology of Bone Consolidation During Distraction Osteogenesis: Bone Lengthening Vs. Bone Transport.Annals of biomedical engineering · 2021Article
- Effects of a contusive spinal cord injury on cortically-evoked spinal spiking activity in rats.Journal of neural engineering · 2020Article
- Real-Time Wireless Platform for In Vivo Monitoring of Bone Regeneration.Sensors (Basel, Switzerland) · 2020Article
- Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.Neurobiology of disease · 2019Article
- Comparison of walking quality variables between incomplete spinal cord injury patients and healthy subjects by using a footscan plantar pressure system.Neural regeneration research · 2019Article
- A Brain-Spinal Interface (BSI) System-on-Chip (SoC) for Closed-Loop Cortically-Controlled Intraspinal Microstimulation.Analog integrated circuits and signal processing · 2018Article
- Motor, Somatosensory, Viscerosensory and Metabolic Impairments in a Heterozygous Female Rat Model of Rett Syndrome.International journal of molecular sciences · 2017Article
- Automated Gait Analysis Through Hues and Areas (AGATHA): A Method to Characterize the Spatiotemporal Pattern of Rat Gait.Annals of biomedical engineering · 2017Article
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Authors and funding
7 authors.
Funding
Abstract
Open-field behavioral scoring is widely used to assess spinal cord injury (SCI) outcomes, but has limited usefulness in describing subtle changes important for posture and locomotion. Additional quantitative methods are needed to increase the resolution of locomotor outcome assessment. This study used gait analysis at multiple speeds (GAMS) across a range of mild-to-severe intensities of thoracic SCI in the rat. Overall, Basso, Beattie, and Bresnahan (BBB) scores and subscores were assessed, and detailed automated gait analysis was performed at three fixed walking speeds (3.5, 6.0, and 8.5 cm/sec). Variability in hindpaw brake, propel, and stance times were analyzed further by integrating across the stance phase of stepping cycles. Myelin staining of spinal cord sections was used to quantify white matter loss at the injury site. Varied SCI intensity produced graded deficits in BBB score, BBB subscores, and spinal cord white matter and total volume loss. GAMS measures of posture revealed decreased paw area, increased limb extension, altered stance width, and decreased values for integrated brake, propel, and stance. Measures of coordination revealed increased stride frequency concomitant with decreased stride length, resulting in deviation from consistent forelimb/hindlimb coordination. Alterations in posture and coordination were correlated to impact severity. GAMS results correlated highly with functional and histological measures and revealed differential relationships between sets of GAMS dynamics and cord total volume loss versus epicenter myelin loss. Automated gait analysis at multiple speeds is therefore a useful tool for quantifying nuanced changes in gait as an extension of histological and observational methods in assessing SCI outcomes.
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