ArticleAnnals of medicine2014
Circadian abnormalities in a mouse model of high trait anxiety and depression.
Article in Annals of medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
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- Repetitive mild traumatic brain injury alters central and peripheral clock gene expression in the adolescent rat.Neurobiology of sleep and circadian rhythms · 2023Article
- Effects of Positive Fighting Experience and Its Subsequent Deprivation on the Expression Profile of Mouse Hippocampal Genes Associated with Neurogenesis.International journal of molecular sciences · 2023Article
- A little goes a long way: Neurobiological effects of low intensity rTMS and implications for mechanisms of rTMS.Current research in neurobiology · 2022Review
- Maternal stress induced anxiety-like behavior exacerbated by electromagnetic fields radiation in female rats offspring.PloS one · 2022Article
- Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype.International journal of molecular sciences · 2021Article
- The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury.Neurobiology of sleep and circadian rhythms · 2020Review
- Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective.Psychiatry investigation · 2020Article
- Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria.Acta neuropathologica communications · 2020Article
- PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model.Translational psychiatry · 2019Article
- Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response.Genes, brain, and behavior · 2019Article
- The role of sleep problems and circadian clock genes in attention-deficit hyperactivity disorder and mood disorders during childhood and adolescence: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- A simplified microwave-based motion detector for home cage activity monitoring in mice.Journal of biological engineering · 2017Article
- Individual differences in circadian locomotor parameters correlate with anxiety- and depression-like behavior.PloS one · 2017Article
- Disrupted Ultradian Activity Rhythms and Differential Expression of Several Clock Genes in Interleukin-6-Deficient Mice.Frontiers in neurology · 2017Article
- Maternal immune activation epigenetically regulates hippocampal serotonin transporter levels.Neurobiology of stress · 2016Article
- Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior.Annals of medicine · 2016Article
- Anhedonic behavior in cryptochrome 2-deficient mice is paralleled by altered diurnal patterns of amygdala gene expression.Amino acids · 2015Article
- d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption.The European journal of neuroscience · 2015Article
- STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior.Scientific reports · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionDysregulation of circadian rhythms is a key symptom of mood disorders, including anxiety disorders and depression. Whether the circadian abnormalities observed in depressed patients are cause or consequence of the disease remains elusive. Here we aimed to explore potential disturbances of circadian rhythms in a validated genetic animal model of high trait anxiety and co-morbid depression and examine its molecular correlates. MATERIALS AND
methodsMice selectively bred for high (HAB) and normal (NAB) anxiety- and co-segregating depression-like behavior were subjected to analysis of circadian wheel-running activity to determine light-entrained (LD) and free-running circadian (DD) rhythms and a light-induced phase shift. Clock gene expression in HAB/NAB hippocampal tissue was analyzed by qRT-PCR and verified by Western blotting.
resultsCompared to NABs, HAB mice were found to present with altered DD length of daily cycle, fragmented ultradiem rhythms, and a blunted phase shift response. Clock gene expression analysis revealed a selective reduction of Cry2 expression in hippocampal tissue of HAB mice. DISCUSSION: We provide first evidence for a dysregulation of circadian rhythms in a mouse model of anxiety and co-morbid depression which suggests an association between depression and altered circadian rhythms at the genetic level and points towards a role for Cry2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.