ArticleBritish journal of pharmacology1987
Interaction of phorbol esters with Ca2+ channels in smooth muscle.
Article in British journal of pharmacology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 26 citations in OpenAlex.
- Contractile and relaxant effects of phorbol ester in the intestinal smooth muscle of guinea-pig taenia caeci.British journal of pharmacology · 1993Article
- Contraction of vascular smooth muscle induced by phorbol 12,13 dibutyrate in human and rat pulmonary arteries.British journal of pharmacology · 1991Article
- The guinea-pig ileum preparation as a model for 5-HT1A receptors: anomalous effects with RS-30199-193.British journal of pharmacology · 1991Article
- An approach to differentiate between noradrenaline-elicited contractile processes in the rat isolated aorta.Naunyn-Schmiedeberg's archives of pharmacology · 1990Article
- A phorbol diester-induced enhancement of synaptic transmission in olfactory cortex.British journal of pharmacology · 1989Article
- Effect of atenolol and pindolol on the phorbol ester-induced coronary vasoconstriction in the isolated perfused heart of the rat.British journal of pharmacology · 1988Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA), a selective activator of protein kinase C, had no effect on the sensitivity to Ca2+ or verapamil of K+-depolarized taenia preparations from the guinea-pig caecum, despite the use of high concentrations (1 microM for 3 h); this preparation is sensitive to Ca2+ channel activators and antagonists. TPA (0.03-3 microM) caused a slow contraction of rat aorta preparations; the contractions were resistant to the calcium-antagonists nifedipine (0.01 microM), verapamil (10 microM), diltiazem (10 microM) and cinnarizine (10 microM), but were antagonized by N-(6-aminohexyl)-5-chloro-1-naphthalensulphonamide (W-7, 50-200 microM). Prolonged exposure to TPA (greater than 2 h) resulted in spontaneous contractions which were sensitive to verapamil (1 microM). Isoprenaline and sodium nitroprusside relaxed phenylephrine-induced contractions in rat aorta preparations. TPA (0.3 microM) blocked the maximal response to isoprenaline but not to sodium nitroprusside indicating that TPA did selectively activate protein kinase C under these experimental conditions. These findings indicate that protein kinase C activation does not result in direct effects on Ca2+ channel function, but may exert effects indirectly (e.g. by modifying intracellular sensitivity to Ca2+, Ca2+ extrusion, or cellular depolarization).
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