ArticleInsect molecular biology2014
Differential gene expression in laboratory strains of human head and body lice when challenged with Bartonella quintana, a pathogenic bacterium.
Article in Insect molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Insect immune systems: same same but different but still same.Frontiers in immunology · 2026Review
- Identification and Spatiotemporal Expression of a Putative New GABA Receptor Subunit in the Human Body LouseGenes · 2024Article
- Lack of paternal silencing and ecotype-specific expression in head and body lice hybrids.Evolution letters · 2024Article
- Immune Reactions of Vector Insects to Parasites and Pathogens.Microorganisms · 2024Review
- High Genetic Diversity andFrontiers in cellular and infection microbiology · 2022Article
- Genetic diversity of human head lice and molecular detection of associated bacterial pathogens in Democratic Republic of Congo.Parasites & vectors · 2019Article
- Where Are We With Human Lice? A Review of the Current State of Knowledge.Frontiers in cellular and infection microbiology · 2019Review
- Detection of bacterial pathogens in clade E head lice collected from Niger's refugees in Algeria.Parasites & vectors · 2018Article
- RETRACTED: Body lice of homeless people reveal the presence of several emerging bacterial pathogens in northern Algeria.PLoS neglected tropical diseases · 2018Article
- Comparison of the proliferation and excretion of Bartonella quintana between body and head lice following oral challenge.Insect molecular biology · 2017Article
- Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Human head and body lice are obligatory hematophagous ectoparasites that belong to a single species, Pediculus humanus. Only body lice, however, are vectors of the infectious Gram-negative bacterium Bartonella quintana. Because of their near identical genomes, yet differential vector competence, head and body lice provide a unique model system to study the gain or loss of vector competence. Using our in vitro louse-rearing system, we infected head and body lice with blood containing B. quintana in order to detect both differences in the proliferation of B. quintana and transcriptional differences of immune-related genes in the lice. B. quintana proliferated rapidly in body lice at 6 days post-infection, but plateaued in head lice at 4 days post-infection. RNAseq and quantitative real-time PCR validation analyses determined gene expression differences. Eight immunoresponse genes were observed to be significantly different with many associated with the Toll pathway: Fibrinogen-like protein, Spaetzle, Defensin 1, Serpin, Scavenger receptor A and Apolipoporhrin 2. Our findings support the hypothesis that body lice, unlike head lice, fight infection from B. quintana only at the later stages of its proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.