ArticlePain research & management
Relationship between bone mineral density and the frequent administration of epidural steroid injections in postmenopausal women with low back pain.
Article in Pain research & management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Safe Use of Epidural Corticosteroid Injections: Recommendations of the WIP Benelux Work Group.Pain practice : the official journal of World Institute of Pain · 2019Guideline
- Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study.Neural plasticity · 2021Trial
- Impact of Menopause and Associated Hormonal Changes on Spine Health in Older Females: A Review.Cells · 2026Review
- [Through the foramen to the nerve root : The new S3 Guideline Epidural Injections].Orthopadie (Heidelberg, Germany) · 2025Review
- Epidural steroid injections and fracture incidence among older individuals with radiculopathy.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Increased Risk of Osteoporotic Vertebral Compression Fractures Following Epidural Steroid Injections in Patients with Lumbar Degenerative Disease: A Retrospective Cohort Study.Journal of clinical medicine · 2024Article
- Fexofenadine As Successful Adjunctive Treatment of Rheumatoid Arthritis and Trochanteric Bursitis: A Case Report.Cureus · 2024Article
- Spine injections: the rationale for CT guidance.Skeletal radiology · 2023Review
- Cumulative glucocorticoid exposure in patients receiving epidural steroid injections: A single-centre retrospective evaluation on 581 procedures against existing clinical recommendations.Interventional pain medicine · 2022Article
- The skeletal consequences of epidural steroid injections: a literature review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Review
- Safety of epidural steroids: a review.Anesthesia and pain medicine · 2021Article
- Comparison of interlaminar CT-guided epidural platelet-rich plasma versus steroid injection in patients with lumbar radicular pain.European radiology · 2020Article
- Effect of Lumbar Epidural Steroid Injections on Osteoporotic Fracture and Bone Mineral Density in Elderly Women with Diabetes Mellitus.Pain research & management · 2020Article
- Effect of medications and epidural steroid injections on fractures in postmenopausal women with osteoporosis.Medicine · 2019Article
- The use of lumbar epidural injection of platelet lysate for treatment of radicular pain.Journal of experimental orthopaedics · 2017Article
- Comparison of the efficacy of saline, local anesthetics, and steroids in epidural and facet joint injections for the management of spinal pain: A systematic review of randomized controlled trials.Surgical neurology international · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidural steroid injection (ESI) is one of the most common nonsurgical treatments for low back pain. In general, corticosteroid therapy often results in bone loss and osteoporosis. In previous studies, bone mineral density (BMD) was evaluated after epidural injections of relatively small numbers and relatively low total doses of corticosteroids. However, the relationship between BMD and multiple ESIs remains to be elucidated.
objectiveTo explore the relationship between BMD and multiple ESIs in postmenopausal women with low back pain.
methodsMedical records of postmenopausal women with low back pain treated with or without ESIs were reviewed. BMD was measured in the lumbar spine, femoral neck and total femur after the treatments. A total of 71 patients were divided into two groups: group 1 included patients who had received non-ESI medications; and group 2 included those who had received ESIs >10 times, with a cumulative administered triamcinolone dose >200 mg.
resultsPatients in group 2 showed lower BMD in the femoral neck and total femur. However, no significant intergroup differences in the BMD of the lumbar spine were observed. The prevalences of osteoporosis and osteopenia in the lumbar spine and femoral neck were significantly higher in group 2; these patients also had lower femoral neck BMD Z-scores.
conclusionsMultiple ESIs (approximately 14 injections with a cumulative triamcinolone dose of approximately 400 mg) can reduce BMD in postmenopausal women with low back pain.
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