ArticleAllergy, asthma & immunology research2014
Eosinophilic airway inflammation and airway hyperresponsiveness according to aeroallergen sensitization pattern in patients with lower airway symptoms.
Article in Allergy, asthma & immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Neutrophil Heterogeneity in Airway Inflammatory Diseases.Inflammation · 2025Review
- Minimizing Indoor Allergen Exposure: What Works?Current allergy and asthma reports · 2024Review
- Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma.Clinical and experimental pediatrics · 2021Article
- Fractional Exhaled Nitric Oxide (FeNO) Integrating Airway Hyperresponsiveness (AHR) Examination Promotes Etiologic Diagnosis and Treatment for Children with Chronic Cough.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Diversity of Soil Filamentous Fungi Influenced by Marine Environment in São Luís, Maranhão, Brazil.TheScientificWorldJournal · 2020Article
- Association Between Sensitization to Mold and Impaired Pulmonary Function in Children With Asthma.Allergy, asthma & immunology research · 2017Article
- Different clinical effect of several types of airborne allergens on the severity of bronchial hyperreactivity.Wiener klinische Wochenschrift · 2017Article
- IgE mediated sensitisation to aeroallergens in an asthmatic cohort: relationship with inflammatory phenotypes and disease severity.International journal of clinical practice · 2016Article
- Detection of Allergen Specific Antibodies From Nasal Secretion of Allergic Rhinitis Patients.Allergy, asthma & immunology research · 2016Article
- Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma.The Korean journal of internal medicine · 2016Article
- Mold allergens in respiratory allergy: from structure to therapy.Allergy, asthma & immunology research · 2015Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSensitization to specific allergens may be important in the development of allergic airway inflammation and airway hyperresponsiveness (AHR). We evaluated the effect of specific aeroallergen sensitization on eosinophilic airway inflammation and AHR.
methodsWe reviewed retrospectively the clinical data of subjects who underwent skin prick tests to aeroallergens, induced sputum analysis, and methacholine bronchial provocation tests to evaluate lower airway symptoms as well as analyzed the associations between the pattern of aeroallergen sensitization and sputum eosinophilia or AHR.
resultsOf the 1,202 subjects be enrolled, 534 (44.4%) were sensitized to at least one aeroallergen in skin tests. AHR was demonstrated in 23.5% and sputum eosinophilia in 38.8%. Sputum eosinophilia was significantly associated with sensitization to perennial allergens (OR, 1.9; 95% CI, 1.4-2.5), house dust mite (OR, 1.7; 95% CI, 1.3-2.3), dog (OR, 1.9; 95% CI, 1.1-3.3), and cat (OR, 2.1; 95% CI, 1.4-3.4). AHR was associated with sensitization to perennial allergens (OR, 2.7; 95% CI, 2.0-3.7), house dust mite (OR, 2.2; 95% CI, 1.6 3.2), Alternaria (OR, 2.3; 95% CI, 1.2-4.7), and cat (OR, 2.7; 95% CI, 1.7-4.3). Sensitization to more perennial allergens increased the risk for sputum eosinophilia and AHR. There was no relationship with individual seasonal allergens.
conclusionThe development of airway eosinophilic inflammation and AHR in an adult Korean population was associated with sensitization to perennial allergens rather than seasonal allergens.
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