SynthesisPloS one2014
Tumor necrosis factor-a polymorphisms and colorectal cancer risk: a meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies.World journal of surgical oncology · 2020Pooled it
- Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis.Bioscience reports · 2019Pooled it
- A trial sequential meta-analysis ofBioscience reports · 2019Pooled it
- Pooled it
- Association of Polymorphisms of Inflammatory-Relevant Genes with Cancer Risk.Current issues in molecular biology · 2026Article
- Biomarkers of inflammation and colorectal cancer risk.Frontiers in oncology · 2025Review
- The Immunomodulatory Effect of Various Anaesthetic Practices in Patients Undergoing Gastric or Colon Cancer Surgery: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Journal of clinical medicine · 2023Review
- Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic (Current issues in molecular biology · 2023Article
- Pharmacological Mechanism of Pingxiao Formula against Colorectal Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study.EBioMedicine · 2020Article
- Effects of the IL6 -174G>C promoter polymorphism and IL-6 serum levels on the progression of cutaneous malignant melanoma.Oncology letters · 2020Article
- Contribution of Genetic Polymorphisms of Inflammation Response Genes on Sporadic Colorectal Cancer Predisposition Risk in Malaysian Patients - A Case Control Study.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk.Molecular carcinogenesis · 2018Article
- Genetic variation in PPARGC1A may affect the role of diet-associated inflammation in colorectal carcinogenesis.Oncotarget · 2017Article
- TNF-α -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China.PloS one · 2017Article
- Article
- Polymorphisms of tumor necrosis factor alpha in Middle Eastern population with colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- TNF-α -308 polymorphisms and male infertility risk: A meta-analysis and systematic review.Journal of advanced research · 2016Review
- Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α(-193) (G/A).Mediators of inflammation · 2015Article
- Exploratory Analysis of VEGF Polymorphisms and Colorectal Cancer Risk in a Hungarian Population: A Case-Control Study.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesTumor necrosis factor-alpha (TNF-a) was related to inflammation and involved in the development of colorectal cancer. Polymorphisms located in TNF-a promoter region, such as 308G/A and 238G/A, could affect the risk of various types of cancer by regulating TNF-a production. In this study, a meta-analysis was performed to investigate the association between common polymorphisms of TNF-a promoter region and colorectal cancer susceptibility.
methodsSearching of several databases was performed for all publications on the association between TNF-a polymorphisms and colorectal cancer. Summary odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated using random-effects models. Stratified analyses based on ethnicity and control population source were also conducted.
resultsOverall, TNF-a 308A polymorphism showed a significant association with increased risk of colorectal cancer in worldwide populations under homozygote comparison [AA vs. GG, OR (95% CI) = 1.46 (1.07-1.97)] other than heterozygote comparison [AG vs. GG, OR (95% CI) = 1.05 (0.93-1.19)]. TNF-a 238A was not associated with colorectal cancer risk under homozygote or heterozygote comparisons. In stratified analysis, significant association was observed only in Western populations [AA vs. GG, OR (95% CI) = 1.39 (1.01-1.91)] other than in Eastern populations under homozygote comparison. No significant difference was observed between population-based subgroup and hospital-based subgroup.
conclusionsTNF-a 308A was moderately associated with an increased risk of colorectal cancer in Western populations, and TNF-a 238A polymorphism was not significantly associated with colorectal cancer risk.
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Registered trials
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