ArticlePloS one2014
Altered spontaneous brain activity in patients with Parkinson's disease accompanied by depressive symptoms, as revealed by regional homogeneity and functional connectivity in the prefrontal-limbic system.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Functional brain changes in Parkinson's disease: a whole brain ALE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Dance movement therapy for neurodegenerative diseases: A systematic review.Frontiers in aging neuroscience · 2022Pooled it
- Consistent decreased activity in the putamen in Parkinson's disease: a meta-analysis and an independent validation of resting-state fMRI.GigaScience · 2018Pooled it
- Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Pooled it
- Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies.European journal of neurology · 2016Pooled it
- Trial
- Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype.NPJ Parkinson's disease · 2025Article
- Accentuated Paralimbic and Reduced Mesolimbic DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Parkinson's Disease Related Depression and Anxiety: A 22-Year Bibliometric Analysis (2000-2022).Neuropsychiatric disease and treatment · 2023Review
- Functional and structural alterations as diagnostic imaging markers for depression inFrontiers in neuroscience · 2023Article
- Regional homogeneity and functional connectivity of freezing of gait conversion in Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- The pathobiological basis of depression in Parkinson disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Depression in Patients with Parkinson's Disease: Current Understanding of its Neurobiology and Implications for Treatment.Drugs & aging · 2022Review
- Directed Brain Connectivity Identifies Widespread Functional Network Abnormalities in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Resting-state brain network in Parkinson's disease with different degrees of depression.Frontiers in neuroscience · 2022Article
- LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition.Frontiers in pharmacology · 2022Article
- Altered Brain Activity in Depression of Parkinson's Disease: A Meta-Analysis and Validation Study.Frontiers in aging neuroscience · 2022Article
- Contributions of sex, depression, and cognition on brain connectivity dynamics in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Aberrant functional connectivity and activity in Parkinson's disease and comorbidity with depression based on radiomic analysis.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As patients with Parkinson's disease (PD) are at high risk for comorbid depression, it is hypothesized that these two diseases are sharing common pathogenic pathways. Using regional homogeneity (ReHo) and functional connectivity approaches, we characterized human regional brain activity at resting state to examine specific brain networks in patients with PD and those with PD and depression (PDD). This study comprised 41 PD human patients and 25 normal human subjects. The patients completed the Hamilton Depression Rating Scale and were further divided into two groups: patients with depressive symptoms and non-depressed PD patients (nD-PD). Compared with the non-depressed patients, those with depressive symptoms exhibited significantly increased regional activity in the left middle frontal gyrus and right inferior frontal gyrus, and decreased ReHo in the left amygdala and bilateral lingual gyrus. Brain network connectivity analysis revealed decreased functional connectivity within the prefrontal-limbic system and increased functional connectivity in the prefrontal cortex and lingual gyrus in PDD compared with the nD-PD group. In summary, the findings showed regional brain activity alterations and disruption of the mood regulation network in PDD patients. The pathogenesis of PDD may be attributed to abnormal neural activity in multiple brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.