ArticlePloS one2014
SHOOT GROWTH1 maintains Arabidopsis epigenomes by regulating IBM1.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- The arabidopsis GyraseB3 contributes to transposon silencing by promoting histone deacetylation.Nucleic acids research · 2025Article
- Growth deficiency and enhanced basal immunity in Arabidopsis thaliana mutants of EDM2, EDM3 and IBM2 are genetically interlinked.PloS one · 2024Article
- Long-read direct RNA sequencing reveals epigenetic regulation of chimeric gene-transposon transcripts in Arabidopsis thaliana.Nature communications · 2023Article
- Intragenic heterochromatin-mediated alternative polyadenylation modulates miRNA and pollen development in rice.The New phytologist · 2021Article
- Transcriptional regulation of genes bearing intronic heterochromatin in the rice genome.PLoS genetics · 2020Article
- The Crosstalk Between Epigenetic Mechanisms and Alternative RNA Processing Regulation.Frontiers in genetics · 2020Review
- Antagonistic Actions of FPA and IBM2 Regulate Transcript Processing from Genes Containing Heterochromatin.Plant physiology · 2019Article
- A protein complex regulates RNA processing of intronic heterochromatin-containing genes inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Epigenetic Regulation of Intronic Transgenes in Arabidopsis.Scientific reports · 2017Article
- An Arabidopsis Natural Epiallele Maintained by a Feed-Forward Silencing Loop between Histone and DNA.PLoS genetics · 2017Article
- A Proposal Regarding Best Practices for Validating the Identity of Genetic Stocks and the Effects of Genetic Variants.The Plant cell · 2016Article
- DNA Methylation within Transcribed Regions.Plant physiology · 2015Review
- Epigenetic regulation of intragenic transposable elements impacts gene transcription in Arabidopsis thaliana.Nucleic acids research · 2015Article
- Ammonium Inhibits Chromomethylase 3-Mediated Methylation of the Arabidopsis Nitrate Reductase Gene NIA2.Frontiers in plant science · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintaining correct DNA and histone methylation patterns is essential for the development of all eukaryotes. In Arabidopsis, we identified SHOOT GROWTH1 (SG1), a novel protein involved in the control of gene methylation. SG1 contains both a Bromo-Adjacent Homology (BAH) domain found in several chromatin regulators and an RNA-Recognition Motif (RRM). The sg1 mutations are associated with drastic pleiotropic phenotypes. The mutants degenerate after few generations and are similar to mutants of the histone demethylase INCREASE IN BONSAI METHYLATION1 (IBM1). A methylome analysis of sg1 mutants revealed a large number of gene bodies hypermethylated in the cytosine CHG context, associated with an increase in di-methylation of lysine 9 on histone H3 tail (H3K9me2), an epigenetic mark normally found in silenced transposons. The sg1 phenotype is suppressed by mutations in genes encoding the DNA methyltransferase CHROMOMETHYLASE3 (CMT3) or the histone methyltransferase KRYPTONITE (KYP), indicating that SG1 functions antagonistically to CMT3 or KYP. We further show that the IBM1 transcript is not correctly processed in sg1, and that the functional IBM1 transcript complements sg1. Altogether, our results suggest a function for SG1 in the maintenance of genome integrity by regulating IBM1.
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