Evidence map›Paper›PMID 24404171›Full record

ArticlePloS one2014

A higher frequency of circulating IL-22(+)CD4(+) T cells in Chinese patients with newly diagnosed Hashimoto's thyroiditis.

Hui Guo, Di Peng, Xi-Ge Yang, Ye Wang, Bing-Chuan Xu, Jin-Song Ni, Wei Meng, Yan-Fang Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Th17 cells in autoimmune and infectious diseases.International journal of inflammation · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hui GuoDepartment of Endocrinology, The Second Part of the First Hospital, Jilin University, Changchun, China.
Di PengKey Laboratory for Zoonosis Research, Department of Central Laboratory, The First Hospital, Jilin University, Changchun, China ; Department of Endocrinology, The Second Part of the First Hospital, Jilin University, Changchun, China.
Xi-Ge YangDepartment of Anesthesiology, The First Hospital, Jilin University, Changchun, China.
Ye WangKey Laboratory for Zoonosis Research, Department of Central Laboratory, The First Hospital, Jilin University, Changchun, China ; Department of Endocrinology, The Second Part of the First Hospital, Jilin University, Changchun, China.
Bing-Chuan XuKey Laboratory for Zoonosis Research, Department of Central Laboratory, The First Hospital, Jilin University, Changchun, China ; Department of Endocrinology, The Second Part of the First Hospital, Jilin University, Changchun, China.
Jin-Song NiDepartment of Pathology, The Second Part of the First Hospital, Jilin University, Changchun, China.
Wei MengDepartment of Thyroid Surgery, The First Hospital, Jilin University, Changchun, China.
Yan-Fang JiangKey Laboratory for Zoonosis Research, Department of Central Laboratory, The First Hospital, Jilin University, Changchun, China.
First Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIL-22 and IL-17A are implicated in the pathogenesis of autoimmune diseases. However, the role of IL-22(+) and IL-17A(+) CD4(+) T cells in the pathogenesis of Hashimoto's thyroiditis (HT) is not fully understood. This study investigates serum IL-22 and IL-17A levels and determines the frequency of circulating IL-22(+) CD4(+) T cells in HT patients to understand their roles in the pathogenesis of HT.

methodsThe levels of serum IL-22, IL-17A and IFN-γ and the frequency of circulating IL-22(+)CD4(+) and IL-17A(+)CD4(+) T cells in 17 HT patients and 17 healthy controls (HC) were determined by enzyme-linked immunosorbent assay (ELISA) and flow cytometry. The levels of serum free triiodothyronine (FT4), free thyroxine (FT3), thyroid stimulating hormone (TSH), anti-thyroid peroxidase (TPO) and anti-thyroglobulin antibodies (TgAb) by chemiluminescent enzyme immunoassay and radioimmunoassay.

resultsThe percentages of circulating IL-22(+)CD4(+) and IL-17(+)CD4(+) T cells (p<0.0001, p<0.0001) and the levels of serum IL-22, IL-17A and IFN-γ (p<0.0001, p<0.0001, p = 0.0210) in the HT patients were significantly higher than that in the HC. The percentages of IL-22(+)CD4(+) T cells were positively correlated with Th17 cells (r = 0.8815, p<0.0001) and IL-17A(+)IL-22(+)CD4(+) T cells (r = 0.8914, p<0.0001), but were negatively correlated with Th1 cells (r = -0.6110, p<0.0092) in the HT patients. The percentages of Th22 cells, Th17 cells and IL-17A(+)IL-22(+)CD4(+) T cells were negatively correlated with the levels of serum TSH in the HT patients (r = -0.8402, p<0.0001; r = -0.8589, p<0.0001; r = -0.8289 p<0.0001, respectively).

conclusionsA higher frequency of circulating IL-22(+)CD4(+) and IL-17A(+)CD4(+) T cells may be associated with the development of HT in Chinese patients.

Indexed as

CD4 Lymphocyte CountAdultAgedCase-Control StudiesCD4-Positive T-LymphocytesChinaHashimoto DiseaseHumansInterferon-gammaInterleukin-17Interleukin-22InterleukinsMaleMiddle AgedThyrotropinT-Lymphocyte SubsetsInterferon-gammaInterleukin-17Interleukin-22InterleukinsThyrotropin

Identifiers

PMID24404171
PMCPMC3880314
OpenAlexW2063909657

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.