ArticlePloS one2014
Effect of dorsal and ventral hippocampal lesions on contextual fear conditioning and unconditioned defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Micro-Stimulation Timing Framed Around an Averaged Theta Period of Stimulation Determines Hippocampal Recruitment in Cued Fear Conditioning.Hippocampus · 2026Article
- Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease.Cells · 2025Review
- Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats.eLife · 2024Article
- Context Processing in Contextual and Cued Fear Extinction.Neuroscience bulletin · 2024Article
- Behavioral effects of environmental enrichment on male and female wistar rats with early life stress experiences.Frontiers in physiology · 2022Article
- Non-human contributions to personality neuroscience - from fish through primates. An introduction to the special issue.Personality neuroscience · 2022Review
- Cortico-limbic pain mechanisms.Neuroscience letters · 2019Review
- Diffusion MRI and MR spectroscopy reveal microstructural and metabolic brain alterations in chronic mild stress exposed rats: A CMS recovery study.NeuroImage · 2018Article
- Brainstem Pain-Control Circuitry Connectivity in Chronic Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Posttraumatic Stress Disorder: Perspectives for the Use of Deep Brain Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2017Review
- Neuroanatomic Differences Associated With Stress Susceptibility and Resilience.Biological psychiatry · 2016Article
- Effects of a Flavonoid-Rich Fraction on the Acquisition and Extinction of Fear Memory: Pharmacological and Molecular Approaches.Frontiers in behavioral neuroscience · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorsal (DH) and ventral (VH) subregions of the hippocampus are involved in contextual fear conditioning. However, it is still unknown whether these two brain areas also play a role in defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray (dPAG). In the present study, rats were implanted with electrodes into the dPAG to determine freezing and escape response thresholds after sham or bilateral electrolytic lesions of the DH or VH. The duration of freezing behavior that outlasted electrical stimulation of the dPAG was also measured. The next day, these animals were subjected to contextual fear conditioning using footshock as an unconditioned stimulus. Electrolytic lesions of the DH and VH impaired contextual fear conditioning. Only VH lesions disrupted conditioned freezing immediately after footshock and increased the thresholds of aversive freezing and escape responses to dPAG electrical stimulation. Neither DH nor VH lesions disrupted post-dPAG stimulation freezing. These results indicate that the VH but not DH plays an important role in aversively defensive behavior induced by dPAG electrical stimulation. Interpretations of these findings should be made with caution because of the fact that a non-fiber-sparing lesion method was employed.
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