ArticleBiomicrofluidics2013
Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- ML-automated microfluidic circuit design.Science advances · 2026Article
- Analysis of Flow Characteristics between Tandem Flexible Structures Based on PIV: Substantial Applications for the Removal of Microplastics.Micromachines · 2024Article
- Deformability-Based Isolation of Circulating Tumor Cells in Spiral Microchannels.Micromachines · 2023Article
- Numerical Modeling of Physical Cell Trapping in Microfluidic Chips.Micromachines · 2023Article
- Incorporation of lateral microfiltration with immunoaffinity for enhancing the capture efficiency of rare cells.Scientific reports · 2020Article
- Microfluidic systems for hydrodynamic trapping of cells and clusters.Biomicrofluidics · 2020Review
- Two-dimensional Simulation of Motion of Red Blood Cells with Deterministic Lateral Displacement Devices.Micromachines · 2019Article
- Efficient Low Shear Flow-based Trapping of Biological Entities.Scientific reports · 2019Article
- Highly efficient and gentle trapping of single cells in large microfluidic arrays for time-lapse experiments.Biomicrofluidics · 2016Article
- A large-area hemispherical perforated bead microarray for monitoring bead based aptamer and target protein interaction.Biomicrofluidics · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computational fluid dynamic (CFD) simulation is a powerful tool in the design and implementation of microfluidic systems, especially for systems that involve hydrodynamic behavior of objects such as functionalized microspheres, biological cells, or biopolymers in complex structures. In this work, we investigate hydrodynamic trapping of microspheres in a novel microfluidic particle-trap array device by finite element simulations. The accuracy of the time-dependent simulation of a microsphere's motion towards the traps is validated by our experimental results. Based on the simulation, we study the fluid velocity field, pressure field, and force and stress on the microsphere in the device. We further explore the trap array's geometric parameters and critical fluid velocity, which affect the microsphere's hydrodynamic trapping. The information is valuable for designing microfluidic devices and guiding experimental operation. Besides, we provide guidelines on the simulation set-up and release an openly available implementation of our simulation in one of the popular FEM softwares, COMSOL Multiphysics. Researchers may tailor the model to simulate similar microfluidic systems that may accommodate a variety of structured particles. Therefore, the simulation will be of particular interest to biomedical research involving cell or bead transport and migration, blood flow within microvessels, and drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.