ArticleBiomicrofluidics2013
Discrimination between the human prostate normal cell and cancer cell by using a novel electrical impedance spectroscopy controlling the cross-sectional area of a microfluidic channel.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- 3D Bioprinting and Microfluidic-based Devices for Cancer Detection and Drug Treatment: Focus on Prostate Cancer.Current medicinal chemistry · 2026Review
- Noninvasive real-time monitoring of cellular spatiotemporal dynamics via machine learning-enhanced electrical impedance spectroscopy.Science advances · 2025Article
- Classification between Normal and Cancerous Human Urothelial Cells by Using Micro-Dimensional Electrochemical Impedance Spectroscopy Combined with Machine Learning.Sensors (Basel, Switzerland) · 2022Article
- Electrical Impedance Spectroscopy for Monitoring Chemoresistance of Cancer Cells.Micromachines · 2020Review
- Learning complex subcellular distribution patterns of proteins via analysis of immunohistochemistry images.Bioinformatics (Oxford, England) · 2020Article
- Increased optical pathlength through aqueous media for the infrared microanalysis of live cells.Analytical and bioanalytical chemistry · 2018Article
- Dielectrophoresis-based microfluidic platforms for cancer diagnostics.Biomicrofluidics · 2018Review
- Improvement of Depth Profiling into Biotissues Using Micro Electrical Impedance Spectroscopy on a Needle with Selective Passivation.Sensors (Basel, Switzerland) · 2016Article
- Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers.BioMed research international · 2016Article
- Microelectrical Impedance Spectroscopy for the Differentiation between Normal and Cancerous Human Urothelial Cell Lines: Real-Time Electrical Impedance Measurement at an Optimal Frequency.BioMed research international · 2016Article
- Ex vivo characterization of age-associated impedance changes of single vascular endothelial cells using micro electrical impedance spectroscopy with a cell trap.Biomicrofluidics · 2016Article
- Spatial concentration distribution analysis of cells in electrode-multilayered microchannel by dielectric property measurement.Biomicrofluidics · 2015Article
- Microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization.International journal of molecular sciences · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prostate biopsy method shows a high false negative result because the suspicious tissue considered as cancer is not confirmed during tissue sampling. Thus, repeated biopsy procedures and diagnostic errors in relation to prostate cancer frequently occur. The purpose of this research is to enhance the prostate cancer detection rate by using microfluidic electrical impedance spectroscopy (μEIS), which allows real-time measurement of the electrical impedance of a single human prostate normal cell and cancer cell. The μEIS was equipped with a movable flexible membrane, which is operated by pneumatic pressure to capture the single cell on the surface of sensing electrodes. The forced tight contact between the cell and electrodes makes it possible to measure the electrical characteristics of the cell with a high sensitivity. The μEIS discriminates well between normal human prostate cells (RWPE-1) and cancer cells (PC-3) at 8.7 kHz based on the electrical signal responses of the cells. The average difference rates of admittance magnitude and susceptance are 54.55% and 54.59%, respectively. The developed μEIS also shows high repeatability, which was verified by a deionized water test conducted before and after each cell assay; the maximum variance of both the impedance and admittance at 8.7 kHz was as small as 9.48%.
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Registered trials
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