ArticleBiomicrofluidics2013
Simulation of malaria-infected red blood cells in microfluidic channels: Passage and blockage.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Microfluidic innovations in chronic kidney disease and renal fibrosis: from mechanistic insights to clinical applications.Frontiers in medicine · 2026Review
- Modeling of Tumor Cell Adhesion, Extravasation, and Sorting in a Microvascular System.Advances in experimental medicine and biology · 2026Article
- Computational methods for inertial microfluidics: recent advances and future perspectives.Microsystems & nanoengineering · 2025Review
- Lattice Boltzmann simulation of deformable fluid-filled bodies: progress and perspectives.Soft matter · 2024Review
- Persistent red blood cells retain their ability to move in microcapillaries under high levels of oxidative stress.Communications biology · 2022Article
- Structural Configuration of Blood Cell Membranes Determines Their Nonlinear Deformation Properties.BioMed research international · 2022Article
- Microfluidic deformability-activated sorting of single particles.Microsystems & nanoengineering · 2020Article
- Quantitative absorption imaging of red blood cells to determine physical and mechanical properties.RSC advances · 2020Article
- Methods to Investigate the Deformability of RBC During Malaria.Frontiers in physiology · 2019Review
- Local Hematocrit Fluctuation Induced by Malaria-Infected Red Blood Cells and Its Effect on Microflow.BioMed research international · 2018Article
- Investigation of red blood cell mechanical properties using AFM indentation and coarse-grained particle method.Biomedical engineering online · 2017Article
- Modeling of Biomechanics and Biorheology of Red Blood Cells in Type 2 Diabetes Mellitus.Biophysical journal · 2017Article
- Computational Biomechanics of Human Red Blood Cells in Hematological Disorders.Journal of biomechanical engineering · 2017Review
- Numerical simulation of a single cell passing through a narrow slit.Biomechanics and modeling in mechanobiology · 2016Article
- MD/DPD Multiscale Framework for Predicting Morphology and Stresses of Red Blood Cells in Health and Disease.PLoS computational biology · 2016Article
- The development of malaria diagnostic techniques: a review of the approaches with focus on dielectrophoretic and magnetophoretic methods.Malaria journal · 2016Review
- A numerical study on the elastic modulus of volume and area dilation for a deformable cell in a microchannel.Biomicrofluidics · 2016Article
- Microfluidic converging/diverging channels optimised for homogeneous extensional deformation.Biomicrofluidics · 2016Article
- Dynamic and rheological properties of soft biological cell suspensions.Rheologica acta · 2016Article
- A Two-Dimensional Numerical Investigation of Transport of Malaria-Infected Red Blood Cells in Stenotic Microchannels.BioMed research international · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria-infected red blood cells (iRBCs) become less deformable with the progression of infection and tend to occlude microcapillaries. This process has been investigated in vitro using microfluidic channels. The objective of this paper is to provide a quantitative basis for interpreting the experimental observations of iRBC occlusion of microfluidic channels. Using a particle-based model for the iRBC, we simulate the traverse of iRBCs through a converging microfluidic channel and explore the progressive loss of cell deformability due to three factors: the stiffening of the membrane, the reduction of the cell's surface-volume ratio, and the growing solid parasites inside the cell. When examined individually, each factor tends to hinder the passage of the iRBC and lengthen the transit time. Moreover, at sufficient magnitude, each may lead to obstruction of narrow microfluidic channels. We then integrate the three factors into a series of simulations that mimic the development of malaria infection through the ring, trophozoite, and schizont stages. These simulations successfully reproduce the experimental observation that with progression of infection, the iRBC transitions from passage to blockage in larger and larger channels. The numerical results suggest a scheme for quantifying iRBC rigidification through microfluidic measurements of the critical pressure required for passage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.