ArticleBiomicrofluidics2013
Label-free electronic probing of nucleic acids and proteins at the nanoscale using the nanoneedle biosensor.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
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- Optimization of process parameters in 3D-nanomaterials printing for enhanced uniformity, quality, and dimensional precision using physics-guided artificial neural network.Discover nano · 2024Article
- PCR-assisted impedimetric biosensor for colibactin-encoding pks genomic island detection in E. coli samples.Analytical and bioanalytical chemistry · 2021Article
- Nanowire gate all around-TFET-based biosensor by considering ambipolar transport.Applied physics. A, Materials science & processing · 2021Article
- A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing World.Sensors (Basel, Switzerland) · 2020Article
- A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Photocatalytic Degradation of Atrazine under Visible Light Using Novel Ag@MgScientific reports · 2019Article
- Nanostructured Tip-Shaped Biosensors: Application of Six Sigma Approach for Enhanced Manufacturing.Sensors (Basel, Switzerland) · 2016Article
- Horizontally Aligned Carbon Nanotube Based Biosensors for Protein Detection.Bioengineering (Basel, Switzerland) · 2016Article
- Portable Cytometry Using Microscale Electronic Sensing.Sensors and actuators. B, Chemical · 2016Article
- Lead-Free Piezoelectric Diaphragm Biosensors Based on Micro-Machining Technology and Chemical Solution Deposition.Sensors (Basel, Switzerland) · 2016Article
- Label and Label-Free Detection Techniques for Protein Microarrays.Microarrays (Basel, Switzerland) · 2015Review
- Quantifying spatio-temporal dynamics of biomarker pre-concentration and depletion in microfluidic systems by intensity threshold analysis.Biomicrofluidics · 2014Article
- Multiplexed actuation using ultra dielectrophoresis for proteomics applications: a comprehensive electrical and electrothermal design methodology.Lab on a chip · 2014Article
- Depletion of cells and abundant proteins from biological samples by enhanced dielectrophoresis.Sensors and actuators. B, Chemical · 2014Article
- Digital microfluidic assay for protein detection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Detection of proteins and nucleic acids is dominantly performed using optical fluorescence based techniques, which are more costly and timely than electrical detection due to the need for expensive and bulky optical equipment and the process of fluorescent tagging. In this paper, we discuss our study of the electrical properties of nucleic acids and proteins at the nanoscale using a nanoelectronic probe we have developed, which we refer to as the Nanoneedle biosensor. The nanoneedle consists of four thin film layers: a conductive layer at the bottom acting as an electrode, an oxide layer on top, and another conductive layer on top of that, with a protective oxide above. The presence of proteins and nucleic acids near the tip results in a decrease in impedance across the sensing electrodes. There are three basic mechanisms behind the electrical response of DNA and protein molecules in solution under an applied alternating electrical field. The first change stems from modulation of the relative permittivity at the interface. The second mechanism is the formation and relaxation of the induced dipole moment. The third mechanism is the tunneling of electrons through the biomolecules. The results presented in this paper can be extended to develop low cost point-of-care diagnostic assays for the clinical setting.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.