Evidence map›Paper›PMID 24404032›Full record

ArticleBiomicrofluidics2013

Parallel generation of uniform fine droplets at hundreds of kilohertz in a flow-focusing module.

David Bardin, Michael R Kendall, Paul A Dayton, Abraham P Lee

Abstract read
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In one paragraph

Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David BardinDepartment of Biomedical Engineering, University of California, Irvine, 3406 Engineering Hall, Irvine, California 92697, USA.
Michael R KendallDepartment of Biomedical Engineering, University of California, Irvine, 3406 Engineering Hall, Irvine, California 92697, USA.
Paul A DaytonJoint Department of Biomedical Engineering, The University of North Carolina and North Carolina State University, Chapel Hill, North Carolina 27599, USA.
Abraham P LeeDepartment of Biomedical Engineering, University of California, Irvine, 3406 Engineering Hall, Irvine, California 92697, USA.

Funding

Precision engineering of ultrasonically-targeted drug delivery vehiclesR01EB008733 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DAYTON, PAUL A · 2009 to 2012
$1.3M
NIBIB NIH HHS R01 EB008733
6 · The paper itself

Abstract

Droplet-based microfluidic systems enable a variety of biomedical applications from point-of-care diagnostics with third world implications, to targeted therapeutics alongside medical ultrasound, to molecular screening and genetic testing. Though these systems maintain the key advantage of precise control of the size and composition of the droplet as compared to conventional methods of production, the low rates at which droplets are produced limits translation beyond the laboratory setting. As well, previous attempts to scale up shear-based microfluidic systems focused on increasing the volumetric throughput and formed large droplets, negating many practical applications of emulsions such as site-specific therapeutics. We present the operation of a parallel module with eight flow-focusing orifices in the dripping regime of droplet formation for the generation of uniform fine droplets at rates in the hundreds of kilohertz. Elevating the capillary number to access dripping, generation of monodisperse droplets of liquid perfluoropentane in the parallel module exceeded 3.69 × 10(5) droplets per second, or 1.33 × 10(9) droplets per hour, at a mean diameter of 9.8 μm. Our microfluidic method offers a novel means to amass uniform fine droplets in practical amounts, for instance, to satisfy clinical needs, with the potential for modification to form massive amounts of more complex droplets.

Identifiers

PMID24404032
PMCPMC3702567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.