ArticleBiomicrofluidics2013
Microfluidic device for trapping and monitoring three dimensional multicell spheroids using electrical impedance spectroscopy.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Sonic snares: Trapping microorganisms for deeper insights into swimming behavior and ciliary dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Simple Micromilled Microfluidic Impedance Cytometer with Vertical Parallel Electrodes for Cell Viability Analysis.Micromachines · 2023Article
- Dielectric Spectroscopy Based Detection of Specific and Nonspecific Cellular Mechanisms.Sensors (Basel, Switzerland) · 2021Article
- Microfluidic device for primary tumor spheroid isolation.Experimental hematology & oncology · 2017Article
- Improvement of Depth Profiling into Biotissues Using Micro Electrical Impedance Spectroscopy on a Needle with Selective Passivation.Sensors (Basel, Switzerland) · 2016Article
- Electrochemical monitoring-on-chip (E-MoC) of HIV-infection in presence of cocaine and therapeutics.Biosensors & bioelectronics · 2016Article
- Automated, Multiplexed Electrical Impedance Spectroscopy Platform for Continuous Monitoring of Microtissue Spheroids.Analytical chemistry · 2016Article
- Electrical Impedance Spectroscopy for Microtissue Spheroid Analysis in Hanging-Drop Networks.ACS sensors · 2016Article
- Nano-biosensors to detect beta-amyloid for Alzheimer's disease management.Biosensors & bioelectronics · 2016Review
- Microfluidic platform for assessing pancreatic islet functionality through dielectric spectroscopy.Biomicrofluidics · 2015Article
- Spatial concentration distribution analysis of cells in electrode-multilayered microchannel by dielectric property measurement.Biomicrofluidics · 2015Article
- Quantitative impedimetric monitoring of cell migration under the stimulation of cytokine or anti-cancer drug in a microfluidic chip.Biomicrofluidics · 2015Article
- Chip based single cell analysis for nanotoxicity assessment.The Analyst · 2014Review
- Quantifying the volume of single cells continuously using a microfluidic pressure-driven trap with media exchange.Biomicrofluidics · 2014Article
- Discrimination between the human prostate normal cell and cancer cell by using a novel electrical impedance spectroscopy controlling the cross-sectional area of a microfluidic channel.Biomicrofluidics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we report the design, fabrication, and testing of a lab-on-a-chip based microfluidic device for application of trapping and measuring the dielectric properties of microtumors over time using electrical impedance spectroscopy (EIS). Microelectromechanical system (MEMS) techniques were used to embed opposing electrodes onto the top and bottom surfaces of a microfluidic channel fabricated using Pyrex substrate, chrome gold, SU-8, and polydimethylsiloxane. Differing concentrations of cell culture medium, differing sized polystyrene beads, and MCF-7 microtumor spheroids were used to validate the designs ability to detect background conductivity changes and dielectric particle diameter changes between electrodes. The observed changes in cell medium concentrations demonstrated a linear relation to extracted solution resistance (Rs), while polystyrene beads and multicell spheroids induced changes in magnitude consistent with diameter increase. This design permits optical correlation between electrical measurements and EIS spectra.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.