Evidence map›Paper›PMID 24404023›Full record

ArticleBiomicrofluidics2013

Simulation of single DNA molecule stretching and immobilization in a de-wetting two-phase flow over micropillar-patterned surface.

Wei-Ching Liao, Xin Hu, Weixiong Wang, L James Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei-Ching LiaoDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio 43210, USA ; Center for Affordable Nanoengineering of Polymeric Biomedical Devices, 1012 Smith Laboratory, 174 W. 18th Ave., Columbus, Ohio 43210, USA.
Xin HuCenter for Affordable Nanoengineering of Polymeric Biomedical Devices, 1012 Smith Laboratory, 174 W. 18th Ave., Columbus, Ohio 43210, USA.
Weixiong WangCenter for Affordable Nanoengineering of Polymeric Biomedical Devices, 1012 Smith Laboratory, 174 W. 18th Ave., Columbus, Ohio 43210, USA.
L James LeeDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, Ohio 43210, USA ; Center for Affordable Nanoengineering of Polymeric Biomedical Devices, 1012 Smith Laboratory, 174 W. 18th Ave., Columbus, Ohio 43210, USA ; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigate single DNA stretching dynamics in a de-wetting flow over micropillars using Brownian dynamics simulation. The Brownian dynamics simulation is coupled with transient flow field computation through a numerical particle tracking algorithm. The droplet formation on the top of the micropillar during the de-wetting process creates a flow pattern that allows DNA to stretch across the micropillars. It is found that DNA nanowire forms if DNA molecules could extend across the stagnation point inside the connecting water filament before its breakup. It also shows that DNA locates closer to the top wall of the micropillar has higher chance to enter the flow pattern of droplet formation and thus has higher chance to be stretched across the micropillars. Our simulation tool has the potential to become a design tool for DNA manipulation in complex biomicrofluidic devices.

Identifiers

PMID24404023
PMCPMC3676381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.