ReviewBiomicrofluidics2013
Review of microfluidic microbioreactor technology for high-throughput submerged microbiological cultivation.
Review in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Microbioreactor design for eukaryotic cell-based biomedical applications.Frontiers in bioengineering and biotechnology · 2026Review
- Microheater: material, design, fabrication, temperature control, and applications-a role in COVID-19.Biomedical microdevices · 2021Review
- Opto-Microfluidic System for Absorbance Measurements in Lithium Niobate Device Applied to pH Measurements.Sensors (Basel, Switzerland) · 2020Article
- Kidney-on-a-chip: untapped opportunities.Kidney international · 2018Review
- Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells.Journal of visualized experiments : JoVE · 2018Article
- Conceptual Design of Micro-Bioreactors and Organ-on-Chips for Studies of Cell Cultures.Bioengineering (Basel, Switzerland) · 2018Review
- A Microfluidic Chip with Double-Slit Arrays for Enhanced Capture of Single Cells.Micromachines · 2018Article
- Application of Microfluidics in Experimental Ecology: The Importance of Being Spatial.Frontiers in microbiology · 2018Review
- "Do It Yourself" Microbial Cultivation Techniques for Synthetic and Systems Biology: Cheap, Fun, and Flexible.Frontiers in microbiology · 2018Article
- The novel oleaginous bacterium Sphingomonas sp. EGY1 DSM 29616: a value added platform for renewable biodiesel.World journal of microbiology & biotechnology · 2017Article
- Review of Microfluidic Photobioreactor Technology for Metabolic Engineering and Synthetic Biology of Cyanobacteria and Microalgae.Micromachines · 2016Review
- Theory of a microfluidic serial dilution bioreactor for growth of planktonic and biofilm populations.Journal of mathematical biology · 2016Article
- A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies.Frontiers in neuroscience · 2016Article
- A nanoliter microfluidic serial dilution bioreactor.Biomicrofluidics · 2015Article
- Hydrogel-based microfluidic incubator for microorganism cultivation and analyses.Biomicrofluidics · 2015Article
- Study of flow behaviors on single-cell manipulation and shear stress reduction in microfluidic chips using computational fluid dynamics simulations.Biomicrofluidics · 2014Article
- A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays.Lab on a chip · 2013Article
- A pneumatic valve controlled microdevice for bioanalysis.Biomicrofluidics · 2013Article
- Deformation properties between fluid and periodic circular obstacles in polydimethylsiloxane microchannels: Experimental and numerical investigations under various conditions.Biomicrofluidics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial fermentation process development is pursuing a high production yield. This requires a high throughput screening and optimization of the microbial strains, which is nowadays commonly achieved by applying slow and labor-intensive submerged cultivation in shake flasks or microtiter plates. These methods are also limited towards end-point measurements, low analytical data output, and control over the fermentation process. These drawbacks could be overcome by means of scaled-down microfluidic microbioreactors (μBR) that allow for online control over cultivation data and automation, hence reducing cost and time. This review goes beyond previous work not only by providing a detailed update on the current μBR fabrication techniques but also the operation and control of μBRs is compared to large scale fermentation reactors.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.