ArticleBiomicrofluidics2013
Electrokinetic trapping and surface enhanced Raman scattering detection of biomolecules using optofluidic device integrated with a microneedles array.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Review: Microbial analysis in dielectrophoretic microfluidic systems.Analytica chimica acta · 2017Review
- Increasing local density and purity of molecules/bacteria on a sensing surface from diluted blood using 3D hybrid electrokinetics.Biomicrofluidics · 2016Article
- Optofluidic devices with integrated solid-state nanopores.Mikrochimica acta · 2016Article
- Raman Spectroscopy of Optically Trapped Single Biological Micro-Particles.Sensors (Basel, Switzerland) · 2015Review
- Numerical simulation on the opto-electro-kinetic patterning for rapid concentration of particles in a microchannel.Biomicrofluidics · 2015Article
- Electric-Field Enhanced Molecule Detection in Suspension on Assembled Plasmonic Arrays by Raman Spectroscopy.Journal of nanotechnology in engineering and medicine · 2014Article
- Measurement and control of pressure driven flows in microfluidic devices using an optofluidic flow sensor.Biomicrofluidics · 2014Article
- Rapid (<5 min) identification of pathogen in human blood by electrokinetic concentration and surface-enhanced Raman spectroscopy.Scientific reports · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, microneedles which possess sharp tips were utilized to trap and detect the biomolecules. Owing to the large curvature, the tips of the microneedles created a substantially high gradient of electric field under the non-uniform electric field which served as not only the trapping sites but also the substrate for surface enhanced Raman scattering (SERS). Separation of polystyrene microparticles with different sizes and two kinds of biomolecules (Staphylococcus aureus (S. aureus) and the red blood cells (RBCs)) were demonstrated. Moreover, in situ detection of S. aureus was performed immediately after separation was completed. The results showed that, after 15 s of sample collection, the Raman signals of S. aureus were detected and greatly enhanced through SERS effect.
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Registered trials
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