Neurochemicals involved in medullary control of common carotid blood flow.

Chi-Li Gong, Yuk-Man Leung, Ming-Ren Wang, Nai-Nu Lin, Tony Jer-Fu Lee, Jon-Son Kuo

Open access · bronzeAbstract read

In one paragraph

Article in Current neuropharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Chi-Li GongDepartment of Physiology, School of Medicine, China Medical University, Taiwan;

Yuk-Man LeungDepartment of Physiology, School of Medicine, China Medical University, Taiwan; ; Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taiwan;

Ming-Ren WangYuhing Junior College of Health Care and Management, Kaohsiung, Taiwan;

Nai-Nu LinDepartment of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan;

Tony Jer-Fu LeeNeuro-Medical Scientific Center and Center for Vascular Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan; ; Department of Medical Research, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan;

Jon-Son KuoNeuro-Medical Scientific Center and Center for Vascular Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan; ; Department of Medical Research, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan; ; Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan.

China Medical University · TWTzu Chi University · TWMin-Hwei College of Health Care Management · TWTaichung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The common carotid artery (CCA) supplies intra- and extra-cranial vascular beds. An area in the medulla controlling CCA blood flow is defined as the dorsal facial area (DFA) by Kuo et al. in 1987. In the DFA, presynaptic nitrergic and/or glutamatergic fibers innervate preganglionic nitrergic and/or cholinergic neurons which give rise to the preganglionic fibers of the parasympathetic 7th and 9th cranial nerves. Released glutamate from presynaptic nitrergic and/or glutamatergic fibers can activate N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors on preganglionic nitrergic and/or cholinergic neurons. By modulating this glutamate release, several neurochemicals including serotonin, arginine, nitric oxide, nicotine, choline and ATP in the DFA regulate CCA blood flow. Understanding the neurochemical regulatory mechanisms can provide important insights of the physiological roles of the DFA, and may help develop therapeutic strategies for diseases involving CCA blood flow, such as migraine, hypertensive disease, Alzheimer's disease and cerebral ischemic stroke.

Indexed as

Carotid arteryCerebral blood flowMedullaNeurotransmitterParasympathetic nucleusVascular regulation

Identifiers

PMID24403875

DOI10.2174/1570159X113119990044

PMCPMC3763759

OpenAlexW2073250926

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.