ArticleMolecular biology of the cell2014
Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Reassessment of the roles of coronin proteins as actin effectors and in signaling.PLoS biology · 2026Article
- mTORC1 pathway activity biases cell fate choice.Scientific reports · 2024Article
- Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis.Cell death & disease · 2024Article
- Coronin 1-dependent cell density sensing and regulation of the peripheral T cell population size.Oxford open immunology · 2024Review
- Cdc42/Rac Interactive Binding Containing Effector Proteins in Unicellular Protozoans With Reference to Human Host: Locks of the Rho Signaling.Frontiers in genetics · 2022Review
- Review
- Interactome and F-Actin Interaction Analysis ofInternational journal of molecular sciences · 2020Article
- Article
- Coronin 1 Is Required for Integrin β2 Translocation in Platelets.International journal of molecular sciences · 2020Article
- From Phagocytes to Immune Defense: Roles for Coronin Proteins inFrontiers in cellular and infection microbiology · 2018Review
- Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays.Journal of visualized experiments : JoVE · 2016Article
- Self-organization of chemoattractant waves in Dictyostelium depends on F-actin and cell-substrate adhesion.Journal of the Royal Society, Interface · 2016Article
- Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many biological systems respond to environmental changes by activating intracellular signaling cascades, resulting in an appropriate response. One such system is represented by the social amoeba Dictyostelium discoideum. When food sources become scarce, these unicellular cells can initiate a cAMP-driven multicellular aggregation program to ensure long-term survival. On starvation, the cells secrete conditioned medium factors that initiate cAMP signal transduction by inducing expression of genes such as cAMP receptors and adenylate cyclase. The mechanisms involved in the activation of the first pulses of cAMP release have been unclear. We here show a crucial role for the evolutionarily conserved protein coronin A in the initiation of the cAMP response. On starvation, coronin A-deficient cells failed to up-regulate the expression of cAMP-regulated genes, thereby failing to initiate development, despite a normal prestarvation response. Of importance, external addition of cAMP to coronin A-deficient cells resulted in normal chemotaxis and aggregate formation, thereby restoring the developmental program and suggesting a functional cAMP relay in the absence of coronin A. These results suggest that coronin A is dispensable for cAMP sensing, chemotaxis, and development per se but is part of a signal transduction cascade essential for system initiation leading to multicellular development in Dictyostelium.
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