ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Can simple rules control development of a pioneer vertebrate neuronal network generating behavior?
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Beyond locomotion: How specialized motor patterns enable a vertebrate to struggle free from capture.iScience · 2025Article
- Structure and Topography of Facial Branchiomotor Neuron Dendrites in Larval Zebrafish (Danio rerio).The Journal of comparative neurology · 2024Article
- Early development of respiratory motor circuits in larval zebrafish (Danio rerio).The Journal of comparative neurology · 2023Article
- Mechanisms Underlying the Recruitment of Inhibitory Interneurons in Fictive Swimming in DevelopingThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes.Nature communications · 2022Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- From decision to action: Detailed modelling of frog tadpoles reveals neuronal mechanisms of decision-making and reproduces unpredictable swimming movements in response to sensory signals.PLoS computational biology · 2021Article
- The Cytoplasmic LIM Domain Protein Espinas Contributes to Photoreceptor Layer Selection in the Visual System.Biology · 2020Article
- High-Dimensional Brain: A Tool for Encoding and Rapid Learning of Memories by Single Neurons.Bulletin of mathematical biology · 2019Article
- The decision to move: response times, neuronal circuits and sensory memory in a simple vertebrate.Proceedings. Biological sciences · 2019Review
- Behavioral Role of the Reciprocal Inhibition between a Pair of Mauthner Cells during Fast Escapes in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times.The Journal of physiology · 2018Article
- Theoretical Models of Neural Development.iScience · 2018Review
- Bifurcations of Limit Cycles in a Reduced Model of the Xenopus Tadpole Central Pattern Generator.Journal of mathematical neuroscience · 2018Article
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- To swim or not to swim: A population-level model of Xenopus tadpole decision making and locomotor behaviour.Bio Systems · 2017Article
- Generative models for network neuroscience: prospects and promise.Journal of the Royal Society, Interface · 2017Review
- Studying the role of axon fasciculation during development in a computational model of the Xenopus tadpole spinal cord.Scientific reports · 2017Article
- Motor Neurons Tune Premotor Activity in a Vertebrate Central Pattern Generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
8 authors.
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Abstract
How do the pioneer networks in the axial core of the vertebrate nervous system first develop? Fundamental to understanding any full-scale neuronal network is knowledge of the constituent neurons, their properties, synaptic interconnections, and normal activity. Our novel strategy uses basic developmental rules to generate model networks that retain individual neuron and synapse resolution and are capable of reproducing correct, whole animal responses. We apply our developmental strategy to young Xenopus tadpoles, whose brainstem and spinal cord share a core vertebrate plan, but at a tractable complexity. Following detailed anatomical and physiological measurements to complete a descriptive library of each type of spinal neuron, we build models of their axon growth controlled by simple chemical gradients and physical barriers. By adding dendrites and allowing probabilistic formation of synaptic connections, we reconstruct network connectivity among up to 2000 neurons. When the resulting "network" is populated by model neurons and synapses, with properties based on physiology, it can respond to sensory stimulation by mimicking tadpole swimming behavior. This functioning model represents the most complete reconstruction of a vertebrate neuronal network that can reproduce the complex, rhythmic behavior of a whole animal. The findings validate our novel developmental strategy for generating realistic networks with individual neuron- and synapse-level resolution. We use it to demonstrate how early functional neuronal connectivity and behavior may in life result from simple developmental "rules," which lay out a scaffold for the vertebrate CNS without specific neuron-to-neuron recognition.
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