ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Neuronal activity-dependent gene dysregulation inAmerican journal of physiology. Cell physiology · 2025Article
- Article
- Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins.eLife · 2025Article
- Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Exercise-induced adaptation of neurons in the vertebrate locomotor system.Journal of sport and health science · 2024Review
- Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.PloS one · 2024Article
- The evolution of mammalian Rem2: unraveling the impact of purifying selection and coevolution on protein function, and implications for human disorders.Frontiers in bioinformatics · 2024Article
- Article
- Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Experience-Dependent Development of Dendritic Arbors in Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes.Cell reports · 2019Article
- Fatherhood alters gene expression within the MPOA.Environmental epigenetics · 2018Article
- The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity.The Journal of biological chemistry · 2018Article
- Neural architecture: from cells to circuits.Journal of neurophysiology · 2018Review
- Article
- The small GTPase RSG1 controls a final step in primary cilia initiation.The Journal of cell biology · 2018Article
- Rem2 signaling affects neuronal structure and function in part by regulation of gene expression.Molecular and cellular neurosciences · 2017Article
- Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development.Journal of neurophysiology · 2017Review
- Two Components of Aversive Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
A key feature of the CNS is structural plasticity, the ability of neurons to alter their morphology and connectivity in response to sensory experience and other changes in the environment. How this structural plasticity is achieved at the molecular level is not well understood. We provide evidence that changes in sensory experience simultaneously trigger multiple signaling pathways that either promote or restrict growth of the dendritic arbor; structural plasticity is achieved through a balance of these opposing signals. Specifically, we have uncovered a novel, activity-dependent signaling pathway that restricts dendritic arborization. We demonstrate that the GTPase Rem2 is regulated at the transcriptional level by calcium influx through L-VGCCs and inhibits dendritic arborization in cultured rat cortical neurons and in the Xenopus laevis tadpole visual system. Thus, our results demonstrate that changes in neuronal activity initiate competing signaling pathways that positively and negatively regulate the growth of the dendritic arbor. It is the balance of these opposing signals that leads to proper dendritic morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.