ArticleJournal of the Royal Society, Interface2014
Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- A Carnitine-Containing Product Improves Aspects of Post-Exercise Recovery in Adult Horses.Animals : an open access journal from MDPI · 2023Article
- Regulators of collagen crosslinking in developing and adult tendons.European cells & materials · 2022Review
- Ultrasound evaluation of the patellar tendon and Achilles tendon and its association with future pain in distance runners.The Physician and sportsmedicine · 2021Article
- Structure-function specialisation of the interfascicular matrix in the human achilles tendon.Acta biomaterialia · 2021Article
- Cyclic tensile tests of Shetland pony superficial digital flexor tendons (SDFTs) with an optimized cryo-clamp combined with biplanar high-speed fluoroscopy.BMC veterinary research · 2021Article
- Interfibrillar shear behavior is altered in aging tendon fascicles.Biomechanics and modeling in mechanobiology · 2020Article
- Bimodal Whole-Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed Tomography.Biological procedures online · 2020Article
- Tendon Biomechanics and Crimp Properties Following Fatigue Loading Are Influenced by Tendon Type and Age in Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Multi-Scale Loading and Damage Mechanisms of Plantaris and Rat Tail Tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Exploiting Viscoelastic Experimental Observations and Numerical Simulations to Infer Biomimetic Artificial Tendon Fiber Designs.Frontiers in bioengineering and biotechnology · 2019Article
- Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission.Scientific reports · 2018Article
- Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM).Acta biomaterialia · 2018Article
- Donor age affects proteome composition of tenocyte-derived engineered tendon.BMC biotechnology · 2018Article
- Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons.Acta biomaterialia · 2017Article
- Tendinopathy: Investigating the Intersection of Clinical and Animal Research to Identify Progress and Hurdles in the Field.JBJS reviews · 2016Article
- Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons.Acta biomaterialia · 2016Article
- Collagen V-heterozygous and -null supraspinatus tendons exhibit altered dynamic mechanical behaviour at multiple hierarchical scales.Interface focus · 2016Article
- The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons.Journal of the mechanical behavior of biomedical materials · 2015Article
- The (dys)functional extracellular matrix.Biochimica et biophysica acta · 2015Review
- Restricted differentiation potential of progenitor cell populations obtained from the equine superficial digital flexor tendon (SDFT).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Some tendons, such as the human Achilles and equine superficial digital flexor tendon (SDFT), act as energy stores, stretching and recoiling to increase efficiency during locomotion. Our previous observations of rotation in response to applied strain in SDFT fascicles suggest a helical structure, which may provide energy-storing tendons with a greater ability to extend and recoil efficiently. Despite this specialization, energy-storing tendons are prone to age-related tendinopathy. The aim of this study was to assess the effect of cyclic fatigue loading (FL) on the microstructural strain response of SDFT fascicles from young and old horses. The data demonstrate two independent age-related mechanisms of fatigue failure; in young horses, FL caused low levels of matrix damage and decreased rotation. This suggests that loading causes alterations to the helix substructure, which may reduce their ability to recoil and recover. By contrast, fascicles from old horses, in which the helix is already compromised, showed greater evidence of matrix damage and suffer increased fibre sliding after FL, which may partially explain the age-related increase in tendinopathy. Elucidation of helix structure and the precise alterations occurring owing to both ageing and FL will help to develop appropriate preventative and repair strategies for tendinopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.