Trial reportThe Laryngoscope2014
Predictors of olfactory dysfunction in rhinosinusitis using the brief smell identification test.
Trial report in The Laryngoscope, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- The Burden of Chronic Rhinosinusitis Without Nasal Polyps: A Systematic Review of Epidemiological, Clinical, Humanistic, and Economic Evidence.Advances in therapy · 2026Pooled it
- The Prevalence of Olfactory Dysfunction in the General Population: A Systematic Review and Meta-analysis.American journal of rhinology & allergy · 2021Pooled it
- The prevalence of olfactory dysfunction in chronic rhinosinusitis.The Laryngoscope · 2017Pooled it
- Association Between Smell Loss, Disease Burden, and Dupilumab Efficacy in Chronic Rhinosinusitis with Nasal Polyps.American journal of rhinology & allergy · 2025Trial
- Defining the minimal clinically important difference for olfactory outcomes in the surgical treatment of chronic rhinosinusitis.International forum of allergy & rhinology · 2017Trial
- Sensitivity analysis and diagnostic accuracy of the Brief Smell Identification Test in patients with chronic rhinosinusitis.International forum of allergy & rhinology · 2016Trial
- Investigation of change in cardinal symptoms of chronic rhinosinusitis after surgical or ongoing medical management.International forum of allergy & rhinology · 2015Trial
- Orthonasal and retronasal olfactory function in patients with chronic rhinosinusitis without nasal polyps undergoing endoscopic sinonasal surgery.International forum of allergy & rhinology · 2025Article
- Use of nonsteroidal anti-inflammatory drugs and poor olfaction in women.International forum of allergy & rhinology · 2024Article
- Smell and Taste Function and Their Disturbances in Sjögren's Syndrome.International journal of environmental research and public health · 2022Review
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Olfactory Change Pattern After Endoscopic Sinus Surgery in Chronic Rhinosinusitis Patients.Cureus · 2022Article
- Quantitative evaluation and progress of olfactory dysfunction in COVID-19.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab.Patient preference and adherence · 2021Article
- Quality-of-life and olfaction changes observed with short-term medical management of chronic rhinosinusitis.International forum of allergy & rhinology · 2020Observational
- Diseases of the nasal cavity.Handbook of clinical neurology · 2019Review
- Establishing the minimal clinically important difference for the Questionnaire of Olfactory Disorders.International forum of allergy & rhinology · 2018Article
- Chronic rhinosinusitis and endoscopic sinus surgery.World journal of otorhinolaryngology - head and neck surgery · 2018Review
- Comparison of Olfactory Function before and After Endoscopic Sinus Surgery.Iranian journal of otorhinolaryngology · 2018Article
- Role of tissue eosinophils in chronic rhinosinusitis-associated olfactory loss.International forum of allergy & rhinology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectives/hypothesisAssociations between olfactory function to quality-of-life (QOL) and disease severity in patients with rhinosinusitis is poorly understood. We sought to evaluate and compare olfactory function between subgroups of patients with rhinosinusitis using the Brief Smell Identification Test (B-SIT). STUDY
designCross-sectional evaluation of a multicenter cohort.
methodsPatients with recurrent acute sinusitis and chronic rhinosinusitis with and without nasal polyposis were prospectively enrolled from three academic tertiary care sites. Each subject completed the B-SIT, in addition to measures of disease-specific QOL. Patient demographics, comorbidities, and clinical measures of disease severity were compared between patients with normal (BSIT≥9) and abnormal (BSIT<9) olfaction scores. Regression modeling was used to identify potential risk factors associated with olfactory impairment.
resultsPatients with rhinosinusitis (n=445) were found to suffer olfactory dysfunction as measured by the B-SIT (28.3%). Subgroups of rhinosinusitis differed in the degree of olfactory dysfunction reported. Worse disease severity, measured by computed tomography and nasal endoscopy, correlated to worse olfaction. Olfactory scores did not consistently correlate with the Rhinosinusitis Disability Index or Sinonasal Outcome Test scores. Regression models demonstrated nasal polyposis was the strongest predictor of olfactory dysfunction. Recalcitrant disease and aspirin intolerance were strongly predictive of worse olfactory function.
conclusionsOlfactory dysfunction is a complex, multifactorial process found to be differentially expressed within subgroups of rhinosinusitis. Olfaction was associated with disease severity as measured by imaging and endoscopy, with only weak associations to disease-specific QOL measures. LEVEL OF EVIDENCE: 2b.
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