ReviewGut2014
Recent advances in clinical practice challenges and opportunities in the management of obesity.
Review in Gut, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Changes in Time of Gastric Emptying After Surgical and Endoscopic Bariatrics and Weight Loss: A Systematic Review and Meta-Analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020Pooled it
- The Influence of the Orbera Intragastric Balloon Filling Volumes on Weight Loss, Tolerability, and Adverse Events: a Systematic Review and Meta-Analysis.Obesity surgery · 2017Pooled it
- Long-term effects of bariatric surgery on type II diabetes, hypertension and hyperlipidemia: a meta-analysis and meta-regression study with 5-year follow-up.Obesity surgery · 2015Pooled it
- Trial
- Semaglutide 2.4 mg for the Treatment of Obesity: Key Elements of the STEP Trials 1 to 5.Obesity (Silver Spring, Md.) · 2020 · on this mapTrial
- Quantitative gastrointestinal and psychological traits associated with obesity and response to weight-loss therapy.Gastroenterology · 2015Trial
- A Multidisciplinary Perspective on Semaglutide Treatment and Medical Nutrition Therapy in Obesity Management.Current obesity reports · 2025Review
- Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway.Journal of biomedical science · 2025Article
- Challenges and strategies for cultivating young teachers in pathophysiology departments at Chinese medical colleges: a narrative review.Ewha medical journal · 2025Review
- Sophoridine Counteracts Obesity via Src-Mediated Inhibition of VEGFR Expression and PI3K/AKT Phosphorylation.International journal of molecular sciences · 2024Article
- Investigating the anti-obesity potential ofFrontiers in pharmacology · 2024Article
- Homeostatic regulation of food intake.Clinics and research in hepatology and gastroenterology · 2022Review
- Obesity as a risk factor for cardiac arrhythmias.BMJ medicine · 2022Review
- Healthy plant-based diet index as a determinant of bone mineral density in osteoporotic postmenopausal women: A case-control study.Frontiers in nutrition · 2022Article
- Glucagon-like peptide-1, a matter of taste?Reviews in endocrine & metabolic disorders · 2021Review
- Association of gastric emptying with postprandial appetite and satiety sensations in obesity.Obesity (Silver Spring, Md.) · 2021Article
- Contemporary Classification of Glucagon-Like Peptide 1 Receptor Agonists (GLP1RAs).Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Review
- Gastric Sensory and Motor Functions and Energy Intake in Health and Obesity-Therapeutic Implications.Nutrients · 2021Review
- Intragastric satiety-inducing device reduces food intake and suppresses body weight gain in a rodent model.Surgical endoscopy · 2021Article
- Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Despite advances in understanding the roles of adiposity, food intake, GI and adipocyte-related hormones, inflammatory mediators, the gut-brain axis and the hypothalamic nervous system in the pathophysiology of obesity, the effects of different therapeutic interventions on those pathophysiological mechanisms are controversial. There are still no low-cost, safe, effective treatments for obesity and its complications. Currently, bariatric surgical approaches targeting the GI tract are more effective than non-surgical approaches in inducing weight reduction and resolving obesity-related comorbidities. However, current guidelines emphasise non-surgical approaches through lifestyle modification and medications to achieve slow weight loss, which is not usually sustained and may be associated with medication-related side effects. This review analyses current central, peripheral or hormonal targets to treat obesity and addresses challenges and opportunities to develop novel approaches for obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.