ArticleJournal of clinical monitoring and computing2014
Evaluation of a computer program for non-invasive determination of pulmonary shunt and ventilation-perfusion mismatch.
Article in Journal of clinical monitoring and computing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Use of ventilation/perfusion mismatch to guide individualised CPAP level selection in preterm infants: a feasibility trial.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Respiratory Function in Ventilated Newborn Infants Nursed Prone and Supine.Pediatric pulmonology · 2025Observational
- Functional morphometry: non-invasive estimation of the alveolar surface area in extremely preterm infants.Pediatric research · 2023Article
- ICG clearance test based on photoacoustic imaging for assessment of human liver function reserve: An initial clinical study.Photoacoustics · 2023Article
- Unstable SpOFrontiers in physiology · 2023Article
- Pathophysiology of gas exchange impairment in extreme prematurity: Insights from combining volumetric capnography and measurements of ventilation/perfusion ratio.Frontiers in pediatrics · 2023Article
- Intrapulmonary shunting is a key contributor to hypoxia in COVID-19: An update on the pathophysiology.PloS one · 2022Article
- Intrapulmonary shunt measured by bedside pulse oximetry predicts worse outcomes in severe COVID-19.The European respiratory journal · 2021Article
- Assessment of liver function reserve by photoacoustic tomography: a feasibility study.Biomedical optics express · 2020Article
- Design of liver functional reserve monitor based on three-wavelength from red light to IR.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018Article
- Ventilation/perfusion ratio and right to left shunt in healthy newborn infants.Journal of clinical monitoring and computing · 2017Article
- Journal of clinical monitoring and computing 2014 end of year summary: respiration.Journal of clinical monitoring and computing · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
We describe a three-compartment model (shunt and two perfused compartments) to analyse the relationship between inspired oxygen (FIO2) and arterial oxygen saturation (SaO2) in terms of pulmonary shunt and ventilation-perfusion ratio (VA/Q). The program was tested using 24 exact datasets, each with six pairs of FIO2 and SaO2 data points with known VA/Q and shunt, generated by a complex calculator of gas exchange. Additional datasets were created by adding noise and rounding the exact sets, and by reducing the number of data points per dataset. The importance of the oxyhaemoglobin dissociation curve and the arterio-venous difference in oxygen content (avDO2) were also tested. Analysis using the three compartment model was more accurate than the two compartment model and less affected by data degradation. The absolute error in shunt estimation was never more than 2.2 % for the exact and rounded datasets, but the error in VA/Q estimation was -29 to 19 % of the true value (10th-90th centiles). The characteristics of the well-ventilated compartment were not determined accurately. At extremes of cardiac output, an assumed value of avDO2 resulted in significant errors. It is probably advantageous to correct for foetal haemoglobin in neonatal datasets. Analysis of FIO2 versus SaO2 datasets using a three compartment model provides accurate estimates of shunt and VA/Q when arterio-venous difference in oxygen content is known. The estimates may have value as objective measures of gas exchange, and as a visual guide for oxygen therapy.
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