Evidence map›Paper›PMID 24402531›Full record

ArticleThe American journal of gastroenterology2014

The etiology of intrahepatic cholestasis of pregnancy: towards solving a monkey puzzle.

Gwilym J Webb, Ahmed M Elsharkawy, Gideon M Hirschfield

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in The American journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gwilym J WebbCentre for Liver Research/NIHR Biomedical Research Unit, Institute of Biomedical Research, University of Birmingham, Birmingham, UK.
Ahmed M ElsharkawyLiver Unit, Queen Elizabeth Hospital, Birmingham, UK.
Gideon M HirschfieldCentre for Liver Research/NIHR Biomedical Research Unit, Institute of Biomedical Research, University of Birmingham, Birmingham, UK.
NIHR Birmingham Liver Biomedical Research Unit · GBQueen Elizabeth Hospital Birmingham · GB

Funding

Medical Research Council MR/M001911/1
6 · The paper itself

Abstract

Clinical and epidemiological findings implicate genetic predisposition and the effects of elevated steroids in pregnancy in the pathogenesis of intrahepatic cholestasis of pregnancy. To date, a number of studies have identified polymorphisms encoding biliary canalicular transporters, including those encoded by ABCB4 and ABCB11, which are associated with intrahepatic cholestasis of pregnancy. Questions remain regarding divergent findings between populations and the relative contributions of these polymorphisms. In a large study of Western European women with intrahepatic cholestasis of pregnancy, Dixon et al. (this issue) provide further insights into the genetics of this cholestatic syndrome, which contribute to ongoing evaluation of cholestasis generally.

Indexed as

ATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 11Cholestasis, IntrahepaticFemaleHumansPregnancyPregnancy ComplicationsABCB11 protein, humanATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 11multidrug resistance protein 3

Identifiers

PMID24402531
OpenAlexW1977733210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.