Evidence map›Paper›PMID 24402392›Full record

ArticleThe journal of nutrition, health & aging2014

Is obesity a marker of robustness in vulnerable hospitalized aged populations? Prospective, multicenter cohort study of 1 306 acutely ill patients.

P-O Lang, R Mahmoudi, J-L Novella, E Tardieu, L-A Bertholon, P Nazeyrollas, F Blanchard, D Jolly, M Dramé

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of nutrition, health & aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02834728 (Frail Elderly Subjects), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02834728 completednot on this map

Frail Elderly Subjects: Inhospital Pathways and Adverse Outcome After Hospitalisation Via Emergency Department

TypeobservationalSponsorCHU de ReimsRan2001 to 2005Enrolled1,306ConditionsFrail Elderly PeopleArmstelephone interview
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

P-O LangPierre Olivier Lang, MD, MPH, PD, PhD. Nescens Centre of Preventive Medicine, Clinic of Genolier, Route du Muids, 3, CH-1272 Genolier, Switzerland, Phone: + 412236693 09 - fax: + 4122 36693 49-E-mail: polang@nescens.com.
R Mahmoudi
J-L Novella
E Tardieu
L-A Bertholon
P Nazeyrollas
F Blanchard
D Jolly
M Dramé
Université de Reims Champagne-Ardenne · FRCentre Hospitalier Universitaire de Reims · FRCranfield University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe "obesity paradox" is poorly understood in vulnerable older hospitalized populations.

objectivesTo prospectively analyze the impact of body mass index (BMI) and comorbidities on early (6-week), one- and two-year mortality.

designProspective multicenter study with a two-year follow-up of old patients participating in the SAFES cohort study. SETTINGS: Nine university hospitals in France.

participantsPatients aged 75 or older hospitalized in medical divisions through the emergency department. MEASUREMENT: Inpatients' characteristics were obtained through a comprehensive geriatric assessment of inpatients, conducted in the first week of hospitalization. All-cause mortalities at 6-week, one- and two-year were determined using bivariable and multivariable Cox proportional hazard model.

resultsThe SAFES cohort included 1,306 patients, aged 85±6 years, with a majority of women (65%). One- and two-year mortality were inversely associated with BMI ≥30 kg/m2 while early mortality was not, and positively associated with age, burden of comorbidities, walking disorders, level of dependency and presence of a dementia syndrome. Survival rates between patients in low (< 18.0 kg/m2) and intermediate (18-24.9 and 25-29.9 kg/m2) BMI categories were not significant.

conclusionWhile our findings seem to confirm the reality of the "obesity paradox" in vulnerable older hospitalized population, the exact understanding of underlying mechanisms and even the truthfulness of this paradoxical relationship are still fraught with considerable methodological, epidemiological and metabolic challenges.

Indexed as

Body Mass IndexCause of DeathGeriatric AssessmentHospitalizationHospital MortalityActivities of Daily LivingAgedAged, 80 and overAge FactorsComorbidityDementiaEmergency Service, HospitalFemaleFranceHumansMale

Identifiers

PMID24402392
PMCPMC12878474
OpenAlexW1996493723

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.